中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
9期
916-918
,共3页
郭旭梅%马凤云%郭惠平%毕隽芳
郭旭梅%馬鳳雲%郭惠平%畢雋芳
곽욱매%마봉운%곽혜평%필준방
血压晨峰%厄贝沙坦%动态血压%微量白蛋白尿
血壓晨峰%阨貝沙坦%動態血壓%微量白蛋白尿
혈압신봉%액패사탄%동태혈압%미량백단백뇨
Morning blood pressure surge%Irbesartan%Ambulatory blood pressure%Urine microalbuminuria
目的 探讨厄贝沙坦对老年高血压晨峰患者尿微量白蛋白的影响及降压疗效.方法 选择经24 h动态血压监测血压未达标的老年高血压晨峰患者92例,观察睡前加用厄贝沙坦治疗后血压及血压晨峰的变化和对尿微量白蛋白的影响.结果 治疗前92例老年高血压患者24 h平均收缩压(140.1±12.7)mm Hg,晨峰收缩压(45.6±10.8)mm Hg,尿微量白蛋白[(58.6±3.7)mg/L]明显升高,与治疗前比较,睡前加服厄贝沙坦治疗后患者24 h平均收缩压[(129.5±11.8)mm Hg]下降(t=3.18,P＜0.05),晨峰收缩压[(14.2±4.1)mm Hg]下降(t=5.74,P＜0.01),尿微量白蛋白[(31.7±3.1)mg/L]显著降低(t=5.24,P＜0.01).结论 厄贝沙坦可以有效降低老年高血压患者的血压及血压晨峰,提高血压达标率,降低尿微量白蛋白.
目的 探討阨貝沙坦對老年高血壓晨峰患者尿微量白蛋白的影響及降壓療效.方法 選擇經24 h動態血壓鑑測血壓未達標的老年高血壓晨峰患者92例,觀察睡前加用阨貝沙坦治療後血壓及血壓晨峰的變化和對尿微量白蛋白的影響.結果 治療前92例老年高血壓患者24 h平均收縮壓(140.1±12.7)mm Hg,晨峰收縮壓(45.6±10.8)mm Hg,尿微量白蛋白[(58.6±3.7)mg/L]明顯升高,與治療前比較,睡前加服阨貝沙坦治療後患者24 h平均收縮壓[(129.5±11.8)mm Hg]下降(t=3.18,P＜0.05),晨峰收縮壓[(14.2±4.1)mm Hg]下降(t=5.74,P＜0.01),尿微量白蛋白[(31.7±3.1)mg/L]顯著降低(t=5.24,P＜0.01).結論 阨貝沙坦可以有效降低老年高血壓患者的血壓及血壓晨峰,提高血壓達標率,降低尿微量白蛋白.
목적 탐토액패사탄대노년고혈압신봉환자뇨미량백단백적영향급강압료효.방법 선택경24 h동태혈압감측혈압미체표적노년고혈압신봉환자92례,관찰수전가용액패사탄치료후혈압급혈압신봉적변화화대뇨미량백단백적영향.결과 치료전92례노년고혈압환자24 h평균수축압(140.1±12.7)mm Hg,신봉수축압(45.6±10.8)mm Hg,뇨미량백단백[(58.6±3.7)mg/L]명현승고,여치료전비교,수전가복액패사탄치료후환자24 h평균수축압[(129.5±11.8)mm Hg]하강(t=3.18,P＜0.05),신봉수축압[(14.2±4.1)mm Hg]하강(t=5.74,P＜0.01),뇨미량백단백[(31.7±3.1)mg/L]현저강저(t=5.24,P＜0.01).결론 액패사탄가이유효강저노년고혈압환자적혈압급혈압신봉,제고혈압체표솔,강저뇨미량백단백.
Objective To investigate the influence of irbesartan taken before bedtime on morning blood pressure surge and urine microalbuminuria in elderly patients with essential hypertension. Methods Ninety-two patients with uncontrolled hypertension were recruited in this study and their 24-hour ambulatory blood pressure monitoring profiles were collected for analysis. After irbesartan taken before bedtime, its influence on general blood pressure, morning blood pressure surge and urine microalbuminuria was observed. Results Before irbesartan treatment,the average 24-hour ambulatory blood pressure was(140.1 ± 12. 7)mm Hg, the morning blood pressure surge was (45.6 ± 10.8) mm Hg, urine microalbuminuria level was (58.6 ± 3.7) mg/L. After irbesartan treatment,the average 24-hour ambulatory blood pressure decreased to (129. 5 t 11.8) mm Hg (t = 3.18, P ＜ 0.05), the morning blood pressure surge decreased to(14. 2 ±4. 1)mm Hg(t =5.74,P ＜0.01) ,urine microalbuminuria level decreased to(31.7±3.1)mg/L(t =5.24,P＜0.01).Conclusions Irbesartan can effectively reduce the peak morning blood pressure,improve achievement ratio of blood pressure control, decrease urine microalbuminuria level in elderly patients essential hypertension.
