中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2010年
5期
297-299
,共3页
吴升%王选锭%卢小军%郭知学
吳升%王選錠%盧小軍%郭知學
오승%왕선정%로소군%곽지학
老年人%医院获得性下呼吸道感染%口腔脱污染%胃肠动力药
老年人%醫院穫得性下呼吸道感染%口腔脫汙染%胃腸動力藥
노년인%의원획득성하호흡도감염%구강탈오염%위장동력약
Elderly%Hospital-acquired lower respiratory tract infection%Oropharyngeal decontamination%Gastrointestinal excitomotor
目的 探讨口腔脱污染联合胃肠动力药物对预防老年人医院获得性下呼吸道感染(hospital-acquired lower respiratory tract infection,HALRTI)的有效性.方法 选择具有发生HALRTI高危因素的110例老年住院患者,随机分为干预组和对照组.干预组予西吡氯铵含漱液漱口(每次20 mL,2次/d),并口服莫沙比利片(每次5 mg,3次/d).两组下呼吸道感染发生率比较采用精确概率法(单侧),咽拭子培养阳性率与住院时间相关性采用Spearman秩相关检验,采用SPSS 12.0软件包进行统计分析.结果 干预组和对照组的HALRTI发生率分别为2.00%(1/50)和13.73%(7/51),差异有统计学意义(P=0.031).对照组咽拭子培养阳性率随着住院时间延长显著增高(r=0.450,P＜0.05),而干预组咽拭子培养阳性率则无显著增高(r=-0.023,P＞0.05).结论 西吡氯铵含漱液漱口联合莫沙必利口服可有效预防高危老年住院患者HALRTI的发生.
目的 探討口腔脫汙染聯閤胃腸動力藥物對預防老年人醫院穫得性下呼吸道感染(hospital-acquired lower respiratory tract infection,HALRTI)的有效性.方法 選擇具有髮生HALRTI高危因素的110例老年住院患者,隨機分為榦預組和對照組.榦預組予西吡氯銨含漱液漱口(每次20 mL,2次/d),併口服莫沙比利片(每次5 mg,3次/d).兩組下呼吸道感染髮生率比較採用精確概率法(單側),嚥拭子培養暘性率與住院時間相關性採用Spearman秩相關檢驗,採用SPSS 12.0軟件包進行統計分析.結果 榦預組和對照組的HALRTI髮生率分彆為2.00%(1/50)和13.73%(7/51),差異有統計學意義(P=0.031).對照組嚥拭子培養暘性率隨著住院時間延長顯著增高(r=0.450,P＜0.05),而榦預組嚥拭子培養暘性率則無顯著增高(r=-0.023,P＞0.05).結論 西吡氯銨含漱液漱口聯閤莫沙必利口服可有效預防高危老年住院患者HALRTI的髮生.
목적 탐토구강탈오염연합위장동력약물대예방노년인의원획득성하호흡도감염(hospital-acquired lower respiratory tract infection,HALRTI)적유효성.방법 선택구유발생HALRTI고위인소적110례노년주원환자,수궤분위간예조화대조조.간예조여서필록안함수액수구(매차20 mL,2차/d),병구복막사비리편(매차5 mg,3차/d).량조하호흡도감염발생솔비교채용정학개솔법(단측),인식자배양양성솔여주원시간상관성채용Spearman질상관검험,채용SPSS 12.0연건포진행통계분석.결과 간예조화대조조적HALRTI발생솔분별위2.00%(1/50)화13.73%(7/51),차이유통계학의의(P=0.031).대조조인식자배양양성솔수착주원시간연장현저증고(r=0.450,P＜0.05),이간예조인식자배양양성솔칙무현저증고(r=-0.023,P＞0.05).결론 서필록안함수액수구연합막사필리구복가유효예방고위노년주원환자HALRTI적발생.
Objective To evaluate the clinical efficacy of oropharyngeal decontamination combined with gastrointestinal excitomotor in preventing hospital-acquired lower respiratory tract infection(HALRTI)in elderly inpatients. Methods Totally 110 elderly inpatients with high risks of HALRTI were randomized into intervention group and control group. Patients of the intervention group were administrated by cetylpyridinium chloride gargle twice daily for gargling(20 mL for each), combined with moshabili three times daily orally(5 mg for each). Exact Sig. l-sided was performed to compare the occurence of HALRTI,and Spearman test was performed to evaluate the correlation between positive rate of the phyarynx swabs and the hospitalized time. SPSS 12.0 software was used for statistical analyzing. Results Patients suffered from HALRTI were 1 case(2.00%)in intervention group and 7 cases(13.73%)in control group respectively,and the difference was of statistical significance(P ＜ 0.05). As hospitalized time went on, the positive rate of the phyarynx swabs microbial culture in the control group increased(r = 0.450, P ＜ 0.05), while the intervention group showed no significant change during the whole intervention time(r = -0.023, P ＞0.05). Conclusion The combined intervention of oropharyngeal decontamination with the gastrointestinal excitomotor may be beneficial to elderly inpatients with high risk of HALRTI in the prevention of HALRTI.
