CAJ | 학술논문

目的通过职业流行病学调查和基准剂量计算,对职业性铅接触所造成的肾损伤进行危险度评定.方法以浙江某蓄电池生产工厂239名工人为接触组,同地区某厨具厂工人76名为对照组,对工人开展问卷调查与体格检查,采集生物样本.收集车间空气中铅监测资料,计算工人在车间中接触的铅的总量,考查铅外剂量与内剂量之间的关系;以外剂量(铅参考接触剂量)、血铅、尿铅为接触标记,以尿中N-乙酰-β-D-氨基葡萄糖苷酶(UNAG)和尿白蛋白(UALB)(均以尿肌酐进行校正)为效应标记.采用基准剂量计算软件(BMDS 11311)计算基准剂量反应为5%时,各效应标记的血铅、尿铅基准剂量.结果铅的外剂量与内剂量呈正相关(血铅:r=0.466,P<0.01;尿铅:r=0.383,P<0.01),铅接触组的血铅、尿铅水平分别为654.03μg/L、143.45μg/g Cr,明显高于对照组(分别为57.12μg/L、7.20μg/gCr),且呈剂量-效应关系;按照对照组效应指标的95%上限为参考值上限,求得各效应指标的异常发生率与接触指标呈剂量-反应关系;UALB、UNAG的血铅BMDL-05分别为607.76、362.56μg/L,UALB、UNAG的尿铅BMDL-05分别为117.79、78.79 μg/Cr.结论职业铅接触可致肾损伤,且呈剂量-反应关系;使用计算血铅、尿铅BMD的方法能进行职业铅接触的肾损害危险度评定.
목적 통과직업류행병학조사화기준제량계산,대직업성연접촉소조성적신손상진행위험도평정.방법 이절강모축전지생산공엄239명공인위접촉조,동지구모주구엄공인76명위대조조,대공인개전문권조사여체격검사,채집생물양본.수집차간공기중연감측자료,계산공인재차간중접촉적연적총량,고사연외제량여내제량지간적관계;이외제량(연삼고접촉제량)、혈연、뇨연위접촉표기,이뇨중N-을선-β-D-안기포도당감매(UNAG)화뇨백단백(UALB)(균이뇨기항진행교정)위효응표기.채용기준제량계산연건(BMDS 11311)계산기준제량반응위5%시,각효응표기적혈연、뇨연기준제량.결과 연적외제량여내제량정정상관(혈연:r=0.466,P<0.01;뇨연:r=0.383,P<0.01),연접촉조적혈연、뇨연수평분별위654.03μg/L、143.45μg/g Cr,명현고우대조조(분별위57.12μg/L、7.20μg/gCr),차정제량-효응관계;안조대조조효응지표적95%상한위삼고치상한,구득각효응지표적이상발생솔여접촉지표정제량-반응관계;UALB、UNAG적혈연BMDL-05분별위607.76、362.56μg/L,UALB、UNAG적뇨연BMDL-05분별위117.79、78.79 μg/Cr.결론 직업연접촉가치신손상,차정제량-반응관계;사용계산혈연、뇨연BMD적방법능진행직업연접촉적신손해위험도평정.
Objective To assess the risk of renal dysfunction caused by occupational lead exposure through epidemiological investigation. Methods The workers in a battery factory were selected as the subjects for the exposure and effect assessment. The occupational environmental monitoring data was collected and used to calculate the total external dose of lead. The relationship between external dose and internal dose of lead was analyzed. The external dose, blood lead (BPb) and urinary lead (UPb) were used as exposure biomarkers while the urinary N-acetyl- D-glucosamindase (UNAG), and urinary albumin (UALB) were used as the effect biomarkers for the renal dysfunction caused by lead. Software of BMDS (BMDS 11311) was used to calculate BMD.Results The external and internal does of lead was positively correlated (BPb: r=0.466, P 0.01; UPb:r=0.383,P<0..01). The levels of BPb, UPb in exposure group (654.03 μg/L,143.45 μg/g Cr) were significantly higher than those in the control group (57.12 μg/L, 7.20 μg/g Cr), so were UALB, UNAG; in addition, all of them presented significant dose-response relationship. The BPb BMD of UALB, UNAG were 607.76, 362.56 μg/L respectively and the UPb BMD of UALB, UNAG were 117.79, 78.79μg/gCr respectively. Conclusion Occupational lead exposure can cause renal dysfunction, which presents dose-response relationship; the risk assessment of renal dysfunction caused by occupational lead exposure is performed by BMD calculation of BPb and UPb.