CAJ | 학술논문

目的了解我院药品不良反应(ADR)发生的情况与特点,以促进临床合理用药.方法采用回顾性研究分析方法,对我院2008年1月～2010年12月收集到的279例ADR报告,分别从患者性别、年龄、引发ADR的药品种类、给药途径、ADR的主要临床表现、ADR的级别及转归等方面进行统计、分析.结果 279例ADR中,男131例,女148例;21～30岁及≤10岁的年龄段ADR的发生率较高;静脉滴注是引起ADR的主要给药途径,有191例,占68.46%;抗感染药物引起的ADR居首位,有174例,占62.37%;临床表现以皮肤系统及其附件损害为主,有159例,占56.99%;新的严重的ADR有15例.结论医务工作者应加强ADR监测工作,避免或减少ADR的发生,促进临床的合理用药.
목적 료해아원약품불량반응(ADR)발생적정황여특점,이촉진림상합리용약.방법 채용회고성연구분석방법,대아원2008년1월～2010년12월수집도적279례ADR보고,분별종환자성별、년령、인발ADR적약품충류、급약도경、ADR적주요림상표현、ADR적급별급전귀등방면진행통계、분석.결과 279례ADR중,남131례,녀148례;21～30세급≤10세적년령단ADR적발생솔교고;정맥적주시인기ADR적주요급약도경,유191례,점68.46%;항감염약물인기적ADR거수위,유174례,점62.37%;림상표현이피부계통급기부건손해위주,유159례,점56.99%;신적엄중적ADR유15례.결론 의무공작자응가강ADR감측공작,피면혹감소ADR적발생,촉진림상적합리용약.
Objective To study the situation and characteristics of adverse drug reactions (ADR)that occurred in our hospital,and promote clinical rational drug use.Methods Collected 279 ADR cases from 2008 to 2010 in our hospital.Used retrospective analysis method to analyze the sex and age distilbution,drug varieties,route of administration,specific clinical manifestations in ADR,ADR level,and ADR prognosis.Results Among these 279 cases,131 cases are male,and 148 cases are female;those who age from 21 to 30 years and who are younger than 10 years old have the highest ADR incidence rate.Most of the 279 ADR cases are induced by intravenous injection,which occupy 68.46%(191 cases).Antimicrobial drugs were the first category of the drugs that cause ADR,which count for 174 cases (62.37%).The main clinical manifestations are the damage of skin and adnexa,which count for 56.99%(159 cases).New and severe ADR have 15 cases.Conclusion Medical workers should strengthen ADR monitoring to avoid or reduce the incidence of ADR,and promote rational clinical drug use.