中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2011年
1期
36-38
,共3页
刘俊%黄陈%孙晶%胡宏慧%金宇彪%裘正军
劉俊%黃陳%孫晶%鬍宏慧%金宇彪%裘正軍
류준%황진%손정%호굉혜%금우표%구정군
胰腺癌%免疫组织化学%HIF-1α%P-gp%预后
胰腺癌%免疫組織化學%HIF-1α%P-gp%預後
이선암%면역조직화학%HIF-1α%P-gp%예후
Pancreatic carcinomas Immunohistochemistry%HIF-1α%P-gp%Prognosis
目的 检测HIF-1α、P-gp蛋白在胰腺癌组织中的表达,探讨它们的临床病理学意义及其相互之间的相关性.方法 应用免疫组织化学法检测74例胰腺癌组织,10例正常胰腺组织中HIF-1α、P-gp蛋白的表达.结果 HIF-1α、P-gp蛋白在胰腺癌组织中的阳性表达率分别为75.7%和86.5%,而正常胰腺组织中均呈阴性表达(P＜0.05).胰腺癌组织中HIF-1α和P-gp蛋白的表达呈显著正相关(r=0.304,P=0.009).胰腺癌组织中的HIF-1α蛋白表达与淋巴结转移、TNM分期呈正相关(P＜0.05);胰腺癌组织中的P-gp蛋白表达与淋巴结转移呈正相关,P-gp高表达与年龄大于60岁有关(P＜0.05).HIF-1α和P-gp蛋白高表达者的中位生存期明显短于低表达者(P＜0.05).结论 胰腺癌组织中HIF-1α、P-gp蛋白的表达上调,HIF-1α和P-gp呈正相关.胰腺癌组织中HIF-1α和P-gp蛋白的表达与淋巴结转移呈正相关.胰腺癌组织中HIF-1α和P-gp蛋白的高表达与预后差有关.
目的 檢測HIF-1α、P-gp蛋白在胰腺癌組織中的錶達,探討它們的臨床病理學意義及其相互之間的相關性.方法 應用免疫組織化學法檢測74例胰腺癌組織,10例正常胰腺組織中HIF-1α、P-gp蛋白的錶達.結果 HIF-1α、P-gp蛋白在胰腺癌組織中的暘性錶達率分彆為75.7%和86.5%,而正常胰腺組織中均呈陰性錶達(P＜0.05).胰腺癌組織中HIF-1α和P-gp蛋白的錶達呈顯著正相關(r=0.304,P=0.009).胰腺癌組織中的HIF-1α蛋白錶達與淋巴結轉移、TNM分期呈正相關(P＜0.05);胰腺癌組織中的P-gp蛋白錶達與淋巴結轉移呈正相關,P-gp高錶達與年齡大于60歲有關(P＜0.05).HIF-1α和P-gp蛋白高錶達者的中位生存期明顯短于低錶達者(P＜0.05).結論 胰腺癌組織中HIF-1α、P-gp蛋白的錶達上調,HIF-1α和P-gp呈正相關.胰腺癌組織中HIF-1α和P-gp蛋白的錶達與淋巴結轉移呈正相關.胰腺癌組織中HIF-1α和P-gp蛋白的高錶達與預後差有關.
목적 검측HIF-1α、P-gp단백재이선암조직중적표체,탐토타문적림상병이학의의급기상호지간적상관성.방법 응용면역조직화학법검측74례이선암조직,10례정상이선조직중HIF-1α、P-gp단백적표체.결과 HIF-1α、P-gp단백재이선암조직중적양성표체솔분별위75.7%화86.5%,이정상이선조직중균정음성표체(P＜0.05).이선암조직중HIF-1α화P-gp단백적표체정현저정상관(r=0.304,P=0.009).이선암조직중적HIF-1α단백표체여림파결전이、TNM분기정정상관(P＜0.05);이선암조직중적P-gp단백표체여림파결전이정정상관,P-gp고표체여년령대우60세유관(P＜0.05).HIF-1α화P-gp단백고표체자적중위생존기명현단우저표체자(P＜0.05).결론 이선암조직중HIF-1α、P-gp단백적표체상조,HIF-1α화P-gp정정상관.이선암조직중HIF-1α화P-gp단백적표체여림파결전이정정상관.이선암조직중HIF-1α화P-gp단백적고표체여예후차유관.
Objective To investigate the expression of HIF-1α and P-gp protein in pancreatic carcinoma and determine their clinicopathological significance and the correlation between the expression of HIF-1α, P-gp and the clinical prognosis. Method In samples from 74 cases of pancreatic carcinoma and 10 healthy individuals, the expression of HIF-1α and P-gp were detected by immunohistochemical method. Results The positive expression rate of HIF-1α and P-gp was 75.7% and 86.5%,respectively, which were remarkably higher than that in normal pancreatic tissue (P＜0.05). There was a positive correlation between the expression of HIF-1α and that of P-gp. The aberrant expression of HIF-1α and P-gp was associated with lymph node metastasis but not the location, size, clinical stages and nerve invasion of the tumor. Patients with high intensity of HIF-1α and P-gp expression showed a significantly lower median survival time than those with low intensity expression.Conclusions The expression of HIF-1α and P-gp is up-regulated in pancreatic carcinoma and there is a positive correlation between them. The expression of HIF-1α and P-gp might be related to the lymph node metastasis and poor prognosis.
