CAJ | 학술논문

目的观察膦甲酸钠对乙型重型肝炎的疗效.方法治疗组乙型重型肝炎患者38例,在一般保肝、支持及防治并发症基础上加用膦甲酸钠治疗4周,观察肝、肾脏功能,HBV DNA定量变化及病死率等.结果膦甲酸钠对急性、亚急性乙型重型肝炎患者肝功能有明显影响,SB由300.96±142.80μmol/L下降为57.72±22.15μmol/L,ALT由352.73±168.14u/L下降为36.00±4.10u/L,AST由433.22±169.11u/L下降为50.18±12.52u/L,PT由22.88±12.23(秒)下降为10.11±3.72(秒),CHOL由1.99±1.56mmol/L上升为3.60±2.18mmol/L;膦甲酸钠对慢性乙型重型肝炎患者肝功能亦有明显影响,SB由394.58±179.82mmol/L下降为78.44±23.72μmol/L,ALT由199.44±107.82u/L下降为42.52±27.01u/L,AST由210.00±170.32u/L下降为79.44±40.73u/L,PT由27.81±13.22(秒)下降为16.11±8.34(秒),CHL由0.99±1.68mmol/L上升为2.90±1.99mmol/L.乙型重型肝炎患者血清HBV DNA变化显示,治疗前为3072.58±742.36pg/ml,治疗后为400±80.70pg/ml;对照组则分别为2989.40±800.48pg/ml和2004.58±807.56pg/ml.在68例重型肝炎中,治疗组死亡8例(22%);对照组死亡14例(46%),两组差异显著(P＜0.01).结论膦甲酸钠可以安全有效地治疗乙型重型肝炎,明显降低病死率.
목적관찰련갑산납대을형중형간염적료효.방법치료조을형중형간염환자38례,재일반보간、지지급방치병발증기출상가용련갑산납치료4주,관찰간、신장공능,HBV DNA정량변화급병사솔등.결과련갑산납대급성、아급성을형중형간염환자간공능유명현영향,SB유300.96±142.80μmol/L하강위57.72±22.15μmol/L,ALT유352.73±168.14u/L하강위36.00±4.10u/L,AST유433.22±169.11u/L하강위50.18±12.52u/L,PT유22.88±12.23(초)하강위10.11±3.72(초),CHOL유1.99±1.56mmol/L상승위3.60±2.18mmol/L;련갑산납대만성을형중형간염환자간공능역유명현영향,SB유394.58±179.82mmol/L하강위78.44±23.72μmol/L,ALT유199.44±107.82u/L하강위42.52±27.01u/L,AST유210.00±170.32u/L하강위79.44±40.73u/L,PT유27.81±13.22(초)하강위16.11±8.34(초),CHL유0.99±1.68mmol/L상승위2.90±1.99mmol/L.을형중형간염환자혈청HBV DNA변화현시,치료전위3072.58±742.36pg/ml,치료후위400±80.70pg/ml;대조조칙분별위2989.40±800.48pg/ml화2004.58±807.56pg/ml.재68례중형간염중,치료조사망8례(22%);대조조사망14례(46%),량조차이현저(P＜0.01).결론련갑산납가이안전유효지치료을형중형간염,명현강저병사솔.