国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
13期
812-815
,共4页
纳洛酮%阿片受体拮抗剂%临床应用
納洛酮%阿片受體拮抗劑%臨床應用
납락동%아편수체길항제%림상응용
Naloxone%Opioid receptor antagonist%Clinical application
纳洛酮是一种人工合成的特异性阿片受体拮抗剂,主要用于拮抗吗啡摄入过量治疗,临床应用过程中逐渐发现,它在呼吸系统、循环系统、神经系统、消化系统及心肺复苏、急性中毒的抢救中也有一定的作用.研究证实,纳洛酮可有效地抑制β内啡肽效应,解除β内啡肽对慢性阻塞性肺疾病合并呼吸衰竭患者呼吸中枢的抑制,兴奋呼吸,与传统的呼吸兴奋剂相比有经济、安全及不良反应小的优点.
納洛酮是一種人工閤成的特異性阿片受體拮抗劑,主要用于拮抗嗎啡攝入過量治療,臨床應用過程中逐漸髮現,它在呼吸繫統、循環繫統、神經繫統、消化繫統及心肺複囌、急性中毒的搶救中也有一定的作用.研究證實,納洛酮可有效地抑製β內啡肽效應,解除β內啡肽對慢性阻塞性肺疾病閤併呼吸衰竭患者呼吸中樞的抑製,興奮呼吸,與傳統的呼吸興奮劑相比有經濟、安全及不良反應小的優點.
납락동시일충인공합성적특이성아편수체길항제,주요용우길항마배섭입과량치료,림상응용과정중축점발현,타재호흡계통、순배계통、신경계통、소화계통급심폐복소、급성중독적창구중야유일정적작용.연구증실,납락동가유효지억제β내배태효응,해제β내배태대만성조새성폐질병합병호흡쇠갈환자호흡중추적억제,흥강호흡,여전통적호흡흥강제상비유경제、안전급불량반응소적우점.
Naloxone is a specific synthetic opioid receptor antagonist, mainly being used for the treatment of excessive intake of morphine,the clinical application gradually proves its role in the respiratory system mainly, circulatory system, nervous system, digestive system and cardiopulmonary resuscitation, acute poisoning in the rescue. Research confirmed that naloxone can effectively curb beta-endorphin(β-EP) effect. The lifting of β-EP in chronic obstructive pulmonary disease with respiratory failure in patients with respiratory center in hibition, excite breathing. Compared with the traditional respiratory stimulants, naloxone is economic,safe,and has fewer side effects.