白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2010年
4期
253-256
,共4页
张晓颖%阎影%宋海峰%陈虎
張曉穎%閻影%宋海峰%陳虎
장효영%염영%송해봉%진호
锌指蛋白A20%树突状细胞%NF-κB
鋅指蛋白A20%樹突狀細胞%NF-κB
자지단백A20%수돌상세포%NF-κB
Zinc finger protein A20%Denclritic cell%NF-κB
锌指蛋白A20(A20)是一种具有泛素化修饰作用的锌指蛋白,在肿瘤坏死因子(TNF)、白细胞介素-1(IL-1)和脂多糖(LPS)等诱导刺激下高度表达,并能通过限制NF-κ B活性的方式调节树突状细胞(DC)的成熟、细胞因子的产生及免疫活性.对A20的生物学特征、参与机体免疫反应的途径及其对DC细胞的成熟和功能的影响进行综述.
鋅指蛋白A20(A20)是一種具有汎素化脩飾作用的鋅指蛋白,在腫瘤壞死因子(TNF)、白細胞介素-1(IL-1)和脂多糖(LPS)等誘導刺激下高度錶達,併能通過限製NF-κ B活性的方式調節樹突狀細胞(DC)的成熟、細胞因子的產生及免疫活性.對A20的生物學特徵、參與機體免疫反應的途徑及其對DC細胞的成熟和功能的影響進行綜述.
자지단백A20(A20)시일충구유범소화수식작용적자지단백,재종류배사인자(TNF)、백세포개소-1(IL-1)화지다당(LPS)등유도자격하고도표체,병능통과한제NF-κ B활성적방식조절수돌상세포(DC)적성숙、세포인자적산생급면역활성.대A20적생물학특정、삼여궤체면역반응적도경급기대DC세포적성숙화공능적영향진행종술.
As a zinc finger protein with ubiquitin-modifying activity, A20 is highly expressed in most mammalian cell in response to stimuli of tumor necrosis factor (TNF), lnterleukin-1 (IL-1), lipopolysaccharide (LPS) and other factors. A20 has been found to play a crucial effect in control of the cell maturation, cytokine production and immunostimulatory potency of dendritic cells (DCs) via modulating down-regulation of NF-κB signaling transduction pathway. In this brief review, we descript the biological characteristics of A20 and the involvement of the A20 in the pathway of the immune responses toward to the DC cell maturation and immunostimulatory potency.
