CAJ | 학술논문

目的探讨急性大面积脑梗死并发多器官功能障碍综合征(MODS)与血清CRP水平的相关性,评估CRP在急性大面积脑梗死的预后及并发MODS中的临床价值.方法采用免疫散射比浊法测定50例对照者(对照组)和50例急性脑梗死患者发病1周内的血清CRP水平,其中急性脑梗死未并发MODS患者30例(急性脑梗死组),大面积脑梗死并发MODS患者20例(大面积脑梗死并发MODS组).结果 (1)50例急性脑梗死患者中48例(96%)血清CRP水平≥5 mg/L,对照组50例中3例(6%)血清CRP水平≥5 mg/L,差异有统计学意义(P＜0.0 5).(2)急性脑梗死组和大面积脑梗死并发MODS组血清CRP水平与对照组比较,差异均有统计学意义(P均<0.01);大面积脑梗死并发MODS组血清CRP水平与急性脑梗死组比较差异也有统计学意义(P＜0.01).(3)血清CRP水平<25 mg/L时,急性脑梗死并发MODS的发生率为0;血清CRP水平>/25 mg/L时,随着血清CRP水平的升高,急性脑梗死并发MODS的发生率增高.结论血清CRP水平与病情的严重程度和MODS的发生率呈正相关,血清CRP水平是判断大面积脑梗死预后并发MODS的一个有效指标.
목적 탐토급성대면적뇌경사병발다기관공능장애종합정(MODS)여혈청CRP수평적상관성,평고CRP재급성대면적뇌경사적예후급병발MODS중적림상개치.방법 채용면역산사비탁법측정50례대조자(대조조)화50례급성뇌경사환자발병1주내적혈청CRP수평,기중급성뇌경사미병발MODS환자30례(급성뇌경사조),대면적뇌경사병발MODS환자20례(대면적뇌경사병발MODS조).결과 (1)50례급성뇌경사환자중48례(96%)혈청CRP수평≥5 mg/L,대조조50례중3례(6%)혈청CRP수평≥5 mg/L,차이유통계학의의(P＜0.0 5).(2)급성뇌경사조화대면적뇌경사병발MODS조혈청CRP수평여대조조비교,차이균유통계학의의(P균<0.01);대면적뇌경사병발MODS조혈청CRP수평여급성뇌경사조비교차이야유통계학의의(P＜0.01).(3)혈청CRP수평<25 mg/L시,급성뇌경사병발MODS적발생솔위0;혈청CRP수평>/25 mg/L시,수착혈청CRP수평적승고,급성뇌경사병발MODS적발생솔증고.결론 혈청CRP수평여병정적엄중정도화MODS적발생솔정정상관,혈청CRP수평시판단대면적뇌경사예후병발MODS적일개유효지표.
Objective To investigate the serum C-reactive protein (CRP) level in patients with acute cerebral infarction and acute massive cerebral infarction with multiple organ dysfunction syndrome (MODS),and analyze the clinical value of CRP. Methods The serum CRP level of 50 patients of control group and 50 patients of cerebral infarction admitted to hospital within 7 days (30 patients were admitted into acute cerebral infarction group and 20 patients into acute massive cerebral infarction with MODS group) were determined by immune scatter turbidimetry. Results (1)In cerebral infarction patients,serum CRP level in 48 cases(96%) was equal and over 5 mg/L.In control group,serum CRP level in 3 cases(6%) was equal and over 5 mg/L(P＜0.0 5).(2)The level of serum CRP acute in cerebral infarction group and in acute massive cerebral infarction with MODS group increased significantly than that in control group (P＜0.01).The level of serum CRP in acute massive cerebral infarction with MODS group increased significantly than that in acute cerebral infarction group.(3)When the level of CRP＜25 mg/L,the incidence of MODS in patients with acute cerebral infarction was zero.When the level of CRP≥25 mg/L,the incidence of MODS increased gradually with the rise of CRP. Conclusions There is positive correlation between the serum level of CRP and the severity of acute cerebral infarction and the incidence of MODS.CRP is a useful marker in predicting the prognosis of acute massive cerebral infarction with MODS.