CAJ | 학술논문

目的探讨超声击破微泡效应抑制兔VX_2肿瘤生长的可行性.方法 21只移植有皮下VX_2肿瘤的新西兰大白兔,随机分为超声微泡治疗组、单纯超声组和假照组.经静脉注射脂质微泡的同时,脉冲式聚焦超声直接辐照肿瘤区域.单纯超声组和假照组分别用5 ml生理盐水和超声假照替代,每次10 min,每隔72 h治疗一次,采集各时间点肿瘤二维声像图和超声造影影像,测量肿瘤切面最大直径.结果在30 d的实验周期内,微泡超声治疗组、单纯超声组和假照组的肿瘤平均直径分别从(1.1±0.1)cm、(1.2±0.1)cm、(1.2±0.1)cm生长至(2.1±0.5)cm、(3.0±0.9)cm、(3.4±0.7)cm,微泡超声治疗组肿瘤直径明显小于另两组.结论超声击破微泡效应可阻断肿瘤微循环,有一定的抑制肿瘤生长作用.
목적 탐토초성격파미포효응억제토VX_2종류생장적가행성.방법 21지이식유피하VX_2종류적신서란대백토,수궤분위초성미포치료조、단순초성조화가조조.경정맥주사지질미포적동시,맥충식취초초성직접복조종류구역.단순초성조화가조조분별용5 ml생리염수화초성가조체대,매차10 min,매격72 h치료일차,채집각시간점종류이유성상도화초성조영영상,측량종류절면최대직경.결과 재30 d적실험주기내,미포초성치료조、단순초성조화가조조적종류평균직경분별종(1.1±0.1)cm、(1.2±0.1)cm、(1.2±0.1)cm생장지(2.1±0.5)cm、(3.0±0.9)cm、(3.4±0.7)cm,미포초성치료조종류직경명현소우령량조.결론 초성격파미포효응가조단종류미순배,유일정적억제종류생장작용.
Objective To investigate the feasibility of VX_2 tumor growth inhibition by using ultrasound mediated microbubble disruption.Methods Twenty-one New Zealand white rabbits bearing subcutaneous VX_2tumor were randomly divided into 3 groups for the impact factors including microbubbles(MB)and ultrasound(US).Pulsed focused ultrasound was delivered directly to the tumor surface for ten minutes following intravenous infusion of microbubbles in the experimental(US+MB)group.The two control groups were applied with only saline injection and sham US exposure.The procedure was repeated every 72 hours until the 30th day.Contrast and grey scale ultrasonography were acquired after every treatment to get the tumor perfusion and measurement.Results The diameters were sized every 72h in a course of 30 days.The average maxium diameter of the US+MB,US,and SHAM groups increased from(1.1±0.1)cm,(1.2±0.1)cm,(1.2±0.1)cm to(2.1±0.5)cm,(3.0±0.9)cm,(3.4±0.7)cm,respectively.The maximal diameter of the US+MB group was significantly smaller than those of the two control groups.Conclusions The VX_2 tumor growth can be inhibited by ultrasound mediated microbubbte disruption effects.