CAJ | 학술논문

目的：探讨CEA、CA19-9、CA242和CA72-4四项血清肿瘤标志物在大肠癌的诊断、手术疗效评价和术后检测的临床价值。方法应用免疫放射分析法测定80例大肠癌患者和50例大肠良性疾病患者的CEA、CA19-9、CA242和CA72-4等4项血清肿瘤标志物，并随访2年。结果 4种血清肿瘤标志物CEA、CA19-9、CA242和CA72-4在大肠癌组水平较良性疾病组水平明显升高(P＜0.05);4项血清肿瘤标志物水平在Dukes分期C、D期病例较A、B期病例明显增高；复发转移组病例4种血清肿瘤标志物水平明显升高。结论血清CEA、CA19-9、CA242和CA72-4对大肠癌的临床诊断、手术疗效评价和术后转移复发监测有一定的临床价值，联合检测可提高检测的敏感度、特异度。
목적：탐토CEA、CA19-9、CA242화CA72-4사항혈청종류표지물재대장암적진단、수술료효평개화술후검측적림상개치。방법 응용면역방사분석법측정80례대장암환자화50례대장량성질병환자적CEA、CA19-9、CA242화CA72-4등4항혈청종류표지물，병수방2년。결과 4충혈청종류표지물CEA、CA19-9、CA242화CA72-4재대장암조수평교량성질병조수평명현승고(P＜0.05);4항혈청종류표지물수평재Dukes분기C、D기병례교A、B기병례명현증고；복발전이조병례4충혈청종류표지물수평명현승고。결론 혈청CEA、CA19-9、CA242화CA72-4대대장암적림상진단、수술료효평개화술후전이복발감측유일정적림상개치，연합검측가제고검측적민감도、특이도。
Objective To investigate the clinical value of CEA, CA19-9, CA242 and CA72-4 four serum tumor markers in colorectal cancer diagnosis, surgery and postoperative evaluation of their. Methods Immunohistochemical assay was used in 80 patients with colorectal cancer and 50 cases of colorectal benign diseases to detect the CEA, CA19-9, CA242 and CA72-4 and other four serum tumor markers, with 2-year follow- up. Results Four kinds of serum tumor markers CEA, CA19-9, CA242 and CA72-4 levels in colorectal cancer group were significantly higher than the control group ( P ＜ 0.05 ) ; levels of the four serum tumor markers in patients in Dukes stages C, D were significantly higher than those in Dukes stages A, B;four serum tumor markers were significantly increased in patients with recurrence of metastasis. Conclusion Combined detection of serum CEA, CA19-9, CA242 and CA72-4 has clinical value in diagnosis, surgical treatment evaluation and monitoring of metastasis and recurrence after surgery of colorectal cancer can improve detection sensitivity and specificity.