CAJ | 학술논문

目的观察妇科腔镜手术后患者氟比洛芬酯自控静脉镇痛(PCIA)的效果与不良反应.方法选择ASA Ⅰ～Ⅱ级妇科腔镜手术后行PCIA患者60例,随机均分为两组.芬太尼组术后PCIA予芬太尼500 μg+昂丹司琼8 mg;氟芬组术后PCIA予氟比洛芬酯100 mg+芬太尼250 μg+昂丹司琼8 mg,手术结束前10 min静脉予氟比洛芬酯50 mg为负荷剂量.两组PCIA均以昂丹司琼作为止吐药,均用生理盐水稀释至100ml.两组PCIA泵的设置相同:维持量2ml/h,单次负荷剂量0.5 ml,锁定时间15 min.观察两组术后48h的镇痛评分(VAS)、镇静评分(SS)及不良反应发生率.结果两组术后镇痛及镇静评分差异无显著性(P>0.05),氟芬组药物不良反应发生率低于芬太尼组.结论氟比洛芬酯用于妇科腔镜手术后PCIA,镇痛效果与单纯芬太尼相似,但不良反应明显减少.提高了镇痛质量.
목적 관찰부과강경수술후환자불비락분지자공정맥진통(PCIA)적효과여불량반응.방법 선택ASA Ⅰ～Ⅱ급부과강경수술후행PCIA환자60례,수궤균분위량조.분태니조술후PCIA여분태니500 μg+앙단사경8 mg;불분조술후PCIA여불비락분지100 mg+분태니250 μg+앙단사경8 mg,수술결속전10 min정맥여불비락분지50 mg위부하제량.량조PCIA균이앙단사경작위지토약,균용생리염수희석지100ml.량조PCIA빙적설치상동:유지량2ml/h,단차부하제량0.5 ml,쇄정시간15 min.관찰량조술후48h적진통평분(VAS)、진정평분(SS)급불량반응발생솔.결과 량조술후진통급진정평분차이무현저성(P>0.05),불분조약물불량반응발생솔저우분태니조.결론 불비락분지용우부과강경수술후PCIA,진통효과여단순분태니상사,단불량반응명현감소.제고료진통질량.
Objective To evaluate the effect and side effect of postoperative patient-controlled intravenous analgesia with flurbiprofen axetii in patients underwent laparoscopic surgery in treating women diseases. Methods 60 cases of such patients that should be ASA class Ⅰ or Ⅱ were randomly divided into two groups equally with 30 cases each. Fentanyl Group was given fentanyl 500 μg plus oudansetron 8 mg diluted to 100 ml via PCIA after surgery, flurbiprofen Group was administrated fentanyl 250 μg, and flurbiprofen axetil 100 mg plus ondansetron 8mg diluted 100ml via PCIA after surgery, the loading dose was flurbiprofen axetil 50 mg ten minutes prior to the end of the operates. The PCIA rate was 2 ml/h, blous 0.5 ml, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Results There was no significant difference in analgesia and sedation grade between two groups. The side effects were lower in flurbiprofen Group than those in fentanyl Group. Conclusion Co-administration of flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following laparoscopic surgery.