中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
9期
22-24
,共3页
郭一闽%刘海英%陈亚迟%王忱
郭一閩%劉海英%陳亞遲%王忱
곽일민%류해영%진아지%왕침
镇痛%细胞因子类%氟比洛芬酯
鎮痛%細胞因子類%氟比洛芬酯
진통%세포인자류%불비락분지
Analgesia%Cytokines%Flurbiprofen axetil
目的 观察应用氟比洛芬酯行患者自控静脉镇痛(PCIA)对妇科腹腔镜术后应激反应的影响.方法 择期行妇科腹腔镜手术患者120例,按随机数字表法分为氟比洛芬酯组和舒芬太尼组,每组各60例,术毕F组予氟比洛芬酯4mg/kg,S组予舒芬太尼1.5=μg/kg,分别用0.9%氯化钠稀释至150ml行PCIA.分别于术前、术毕、术后48h检测肿瘤坏死因子(TNF)-α及白细胞介素(IL)-6、IL-8、IL-10水平.结果两组术后疼痛视觉模拟评分(VAS)均小于4分,组间比较差异无统计学意义(P>0.05).两组患者组内和组间TNF-α比较差异均无统计学意义(P>0.05).两组术毕、术后48 hIL-6、IL-8均较术前明显升高(P<0.05),但氟比洛芬酯组[IL-6分别为(18.39±3.01)、(13.43±3.11)ng/L,IL-8分别为(24.25±2.75)、(15.31±2.65)ng/L]明显低于舒芬太尼组[IL-6分别为(38.02±2.95)、(23.28±2.43)ng/L,IL-8分别为(37.56±2.97)、(24.86±3.11)ng/L](P<0.05).两组术毕、术后48 h IL-10均较术前明显升高(P<0.05),但术后48 h氟比洛芬酯组[分别为(26.72±4.41)、(21.03±2.99)ng/L]明显高于舒芬太尼组[分别为(22.18±3.21)、(16.89±4.48)ng/L](P<0.05).结论 氟比洛芬酯用于妇科腹腔镜术后PCIA效果满意,能减轻术后应激反应.
目的 觀察應用氟比洛芬酯行患者自控靜脈鎮痛(PCIA)對婦科腹腔鏡術後應激反應的影響.方法 擇期行婦科腹腔鏡手術患者120例,按隨機數字錶法分為氟比洛芬酯組和舒芬太尼組,每組各60例,術畢F組予氟比洛芬酯4mg/kg,S組予舒芬太尼1.5=μg/kg,分彆用0.9%氯化鈉稀釋至150ml行PCIA.分彆于術前、術畢、術後48h檢測腫瘤壞死因子(TNF)-α及白細胞介素(IL)-6、IL-8、IL-10水平.結果兩組術後疼痛視覺模擬評分(VAS)均小于4分,組間比較差異無統計學意義(P>0.05).兩組患者組內和組間TNF-α比較差異均無統計學意義(P>0.05).兩組術畢、術後48 hIL-6、IL-8均較術前明顯升高(P<0.05),但氟比洛芬酯組[IL-6分彆為(18.39±3.01)、(13.43±3.11)ng/L,IL-8分彆為(24.25±2.75)、(15.31±2.65)ng/L]明顯低于舒芬太尼組[IL-6分彆為(38.02±2.95)、(23.28±2.43)ng/L,IL-8分彆為(37.56±2.97)、(24.86±3.11)ng/L](P<0.05).兩組術畢、術後48 h IL-10均較術前明顯升高(P<0.05),但術後48 h氟比洛芬酯組[分彆為(26.72±4.41)、(21.03±2.99)ng/L]明顯高于舒芬太尼組[分彆為(22.18±3.21)、(16.89±4.48)ng/L](P<0.05).結論 氟比洛芬酯用于婦科腹腔鏡術後PCIA效果滿意,能減輕術後應激反應.
목적 관찰응용불비락분지행환자자공정맥진통(PCIA)대부과복강경술후응격반응적영향.방법 택기행부과복강경수술환자120례,안수궤수자표법분위불비락분지조화서분태니조,매조각60례,술필F조여불비락분지4mg/kg,S조여서분태니1.5=μg/kg,분별용0.9%록화납희석지150ml행PCIA.분별우술전、술필、술후48h검측종류배사인자(TNF)-α급백세포개소(IL)-6、IL-8、IL-10수평.결과량조술후동통시각모의평분(VAS)균소우4분,조간비교차이무통계학의의(P>0.05).량조환자조내화조간TNF-α비교차이균무통계학의의(P>0.05).량조술필、술후48 hIL-6、IL-8균교술전명현승고(P<0.05),단불비락분지조[IL-6분별위(18.39±3.01)、(13.43±3.11)ng/L,IL-8분별위(24.25±2.75)、(15.31±2.65)ng/L]명현저우서분태니조[IL-6분별위(38.02±2.95)、(23.28±2.43)ng/L,IL-8분별위(37.56±2.97)、(24.86±3.11)ng/L](P<0.05).량조술필、술후48 h IL-10균교술전명현승고(P<0.05),단술후48 h불비락분지조[분별위(26.72±4.41)、(21.03±2.99)ng/L]명현고우서분태니조[분별위(22.18±3.21)、(16.89±4.48)ng/L](P<0.05).결론 불비락분지용우부과복강경술후PCIA효과만의,능감경술후응격반응.
Objective To observe the effects of flurbiprofen axetil postoperative patient-controlled intravenous analgesia (PCIA) on stress response in patients undergoing gynecological laparoscopy operation.Methods One hundred and twenty ASA Ⅰ - Ⅱ gynecological laparoscopy operation patients were randomized to two groups, 60 cases in each group.Group F received flurbiprofen axetil 4 mg/kg while group S were given sufentanil 1.5μ g/kg for postoperative PCIA.Tumor necrosis factor-α (TNF-α ) and interleukin (IL)-6, IL-8, IL- 10 were estimated preoperative(T_0), operation termination(T_1) and 48 h after operation(T_2).Results VAS scores were less than 4 scores and no significant difference between two groups.There was no significant difference in TNF- α intraclass and interclass between two groups(P > 0.05 ).IL-6, IL-8, IL- 10 in two groups were significantly higher at T_1 and T_2 than those at To (P< 0.05).IL-6, IL-8 at T_1 and T_2 were lower in group F than those in group S [T_1 and T_2: IL-6 was ( 18.39 ± 3.01 ), ( 13.43 ± 3.11 ) ng/L, IL-8 was (24.25 ± 2.75 ), ( 15.31 ± 2.65 ) ng/L in group F; IL-6 was (38.02 ± 2.95 ), (23.28 ± 2.43 ) ng/L, IL-8 was ( 37.56 ± 2.97 ), ( 24.86 ± 3.11 ) ng/L in group S]( P < 0.05 ).While IL- 10 was significantly higher and lasted longer in group F than that in group S [(26.72±4.41), (21.03±2.99) ng/L in group F; (22.18 ± 3.21), (16.89 ± 4.48) ng/L in group S](P < 0.05).Conclusion PCIA with flurbiprofen axetil in gynecological laparoscopy operation patients can alleviate inflammatory response.
