CAJ | 학술논문

目的探讨下肢动脉粥样硬化性疾病(LEAD)患者股总动脉僵硬度与心功能间的关系.方法选取LEAD患者33例与健康志愿者37例,应用QIMT和QAS技术自动测量左侧股总动脉的内中膜厚度(IMT)、管径、扩张性(DC)、顺应性(CC)、僵硬度参数(α、β)和脉搏波传导速度(PWVβ);应用超声心动图测量室间隔舒张末期厚度(IVSd)、左室舒张末期内径(LVDd)、左室质量(LVM)、射血分数(EF)、E/A、E'/A'、E/E'和Tei指数.对比两组的测量结果,并将股动脉僵硬度参数与左室功能参数进行相关分析.结果 ①LEAD组IMT增厚,α、β和PWVβ高于对照组,DC、CC低于对照组,差异有统计学意义(P＜0.05).②LEAD组IVSd、LVM和E/E'高于对照组,差异有统计学意义(P＜0.05);两组的E/A、E'/A'及Tei指数差异无统计学意义.③E/E'与CC呈负相关,与α、β和PWVβ呈不同程度的正相关(P＜0.05～0.01);E'/A'与IC和CC呈正相关,与α、β和PWVβ呈不同程度的负相关(P＜0.05～0.01);收缩功能参数、Tei指数与股动脉僵硬度各参数相关性均无统计学意义(P＞0.05).结论 LEAD患者左侧股动脉内中膜增厚,动脉僵硬度增高,左室舒张功能受损；股动脉硬化与早期左室舒张功能受损有一定相关.
목적 탐토하지동맥죽양경화성질병(LEAD)환자고총동맥강경도여심공능간적관계.방법 선취LEAD환자33례여건강지원자37례,응용QIMT화QAS기술자동측량좌측고총동맥적내중막후도(IMT)、관경、확장성(DC)、순응성(CC)、강경도삼수(α、β)화맥박파전도속도(PWVβ);응용초성심동도측량실간격서장말기후도(IVSd)、좌실서장말기내경(LVDd)、좌실질량(LVM)、사혈분수(EF)、E/A、E'/A'、E/E'화Tei지수.대비량조적측량결과,병장고동맥강경도삼수여좌실공능삼수진행상관분석.결과 ①LEAD조IMT증후,α、β화PWVβ고우대조조,DC、CC저우대조조,차이유통계학의의(P＜0.05).②LEAD조IVSd、LVM화E/E'고우대조조,차이유통계학의의(P＜0.05);량조적E/A、E'/A'급Tei지수차이무통계학의의.③E/E'여CC정부상관,여α、β화PWVβ정불동정도적정상관(P＜0.05～0.01);E'/A'여IC화CC정정상관,여α、β화PWVβ정불동정도적부상관(P＜0.05～0.01);수축공능삼수、Tei지수여고동맥강경도각삼수상관성균무통계학의의(P＞0.05).결론 LEAD환자좌측고동맥내중막증후,동맥강경도증고,좌실서장공능수손；고동맥경화여조기좌실서장공능수손유일정상관.
Objective To evaluate the correlation between left ventricular function and arterial stiffness of left femoral artery in patients with lower extremity atherosclerotic disease (LEAD).Methods Thirty-three patients with LEAD and 37 healthy subjects (control group) were enrolled in this study.The intima-media thickness (IMT),diameter and parameters of arterial stiffness [dispensability coefficient (DC),compliance coefficient (CC),stiffness α,stiffness β,pulse wave velocity (PWVβ) ]were measured by ultrasonography with the technology of QIMT and QAS.The thickness of the interventricular septum (IVSd),end-diastolic left ventricular diameter (LVDd) and left ventricular mass (LVM),and parameters of the left ventriculsr function (EF,E/A,E'/A',E/E' and Tei index) were measured by echocardiography.These parameters were compared between two groups.Correlations between the parameters of the arterial stiffness and those of the cardiac function were evaluated by Pearson correlative analysis.Results ①The IVSd,LVM and E/E' ratio were significantly higher in LEAD group than those in control group ( P ＜0.05).There were no significant differences in EF,E/A,E'/A',and Tei index between two groups ( P ＞0.05).②The IMT,α,β,PWVβ of left femoral artery were significantly higher in LEAD group than those in control group,while DC and CC were significantly lower in LEAD group than those in control group ( P ＜0.05).③The E/E' ratio,one of the parameters representing the left ventricular diastolic function,was correlated negatively with CC and positively with α,β,and PWVβ ( P ＜0.05 or P ＜0.01 ).The E'/A' ratio was correlated positively with DC and CC,and negatively with α,β,and PWVβ ( P ＜0.05 or P ＜0.01 ).Both EF and Tei index were not significantly correlated with the above parameters of arterial stiffness ( P ＞0.05).Conclusions Patients with LEAD have thickened femoral IMT,higher arterial stiffness of left femoral artery,as well as impaired left ventricular function.There is a close correlation between the atherosclerosis of the femoral artery and the early left vcntricular dysfunction.