中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2009年
4期
431-433
,共3页
邵喜英%许涌%苏丹%许凯声%冯建国%牟翰舟%徐笑红%陈占红%王晓稼
邵喜英%許湧%囌丹%許凱聲%馮建國%牟翰舟%徐笑紅%陳佔紅%王曉稼
소희영%허용%소단%허개성%풍건국%모한주%서소홍%진점홍%왕효가
乳腺癌%基因多态性%等位基因
乳腺癌%基因多態性%等位基因
유선암%기인다태성%등위기인
Breast carcinoma%Gene polymorphism%Allele
目的 探讨乳腺癌易感性与CYP19基因rs4646(C/A)、rs1008805(A/G)多态性的相关性.方法 采用病例对照研究,应用TaqMan法检测233例浙江地区乳腺癌患者及180例正常人CYP19基因rs4646、rs1008805多态性,基因型分布和乳腺癌发病风险、患者年龄、月经状态及肿瘤临床病理特征的关系采用行x列表X2检验;危险度比值比(OR)及95%可信区间(CI)运用非条件Logistic回归分析计算.结果 (1)病例组中,CYP19基因rs4646(C/A)位点CC、AC、AA基因型的频率分别为47.6%、41.6%、10.7%,而对照组中则分别为52.8%、38.3%、8.9%;病例组中,C、A等位基因的频率分别为68.5%、31.5%,而对照组中则分别为71.9%、28.1%.以CC型为对照,AC、AA型没有增加乳腺癌的发生风险(P>0.05),经年龄分层,亦未发现其与乳腺癌易感性相关.(2)病例组中,CYP19基因rs1008805(A/G)位点从、AG、GG基因型的频率分别为44.6%、43.3%、12.0%,而对照组中则分别为51.4%、40.2%、8.4%;病例组中,A、G等位基因的频率分别为66.3%、33.7%.而对照组中则分别为71.5%、28.5%.以AA型为对照,AG、GG型没有增加乳腺癌的发生风险(P>0.05),经年龄分层,亦未发现其与乳腺癌易感性相关.(3)CYP19基因rs4646(CA/A)和rs1008805(X/G)多态性与乳腺癌患者年龄、月经状况及病理特征均无明显相关.结论 CYP19基因m4646、rs1008805多态性与乳腺癌易感性无明显相关,尚不推荐单独作为未来乳腺癌基因筛查的候选指标.
目的 探討乳腺癌易感性與CYP19基因rs4646(C/A)、rs1008805(A/G)多態性的相關性.方法 採用病例對照研究,應用TaqMan法檢測233例浙江地區乳腺癌患者及180例正常人CYP19基因rs4646、rs1008805多態性,基因型分佈和乳腺癌髮病風險、患者年齡、月經狀態及腫瘤臨床病理特徵的關繫採用行x列錶X2檢驗;危險度比值比(OR)及95%可信區間(CI)運用非條件Logistic迴歸分析計算.結果 (1)病例組中,CYP19基因rs4646(C/A)位點CC、AC、AA基因型的頻率分彆為47.6%、41.6%、10.7%,而對照組中則分彆為52.8%、38.3%、8.9%;病例組中,C、A等位基因的頻率分彆為68.5%、31.5%,而對照組中則分彆為71.9%、28.1%.以CC型為對照,AC、AA型沒有增加乳腺癌的髮生風險(P>0.05),經年齡分層,亦未髮現其與乳腺癌易感性相關.(2)病例組中,CYP19基因rs1008805(A/G)位點從、AG、GG基因型的頻率分彆為44.6%、43.3%、12.0%,而對照組中則分彆為51.4%、40.2%、8.4%;病例組中,A、G等位基因的頻率分彆為66.3%、33.7%.而對照組中則分彆為71.5%、28.5%.以AA型為對照,AG、GG型沒有增加乳腺癌的髮生風險(P>0.05),經年齡分層,亦未髮現其與乳腺癌易感性相關.(3)CYP19基因rs4646(CA/A)和rs1008805(X/G)多態性與乳腺癌患者年齡、月經狀況及病理特徵均無明顯相關.結論 CYP19基因m4646、rs1008805多態性與乳腺癌易感性無明顯相關,尚不推薦單獨作為未來乳腺癌基因篩查的候選指標.
목적 탐토유선암역감성여CYP19기인rs4646(C/A)、rs1008805(A/G)다태성적상관성.방법 채용병례대조연구,응용TaqMan법검측233례절강지구유선암환자급180례정상인CYP19기인rs4646、rs1008805다태성,기인형분포화유선암발병풍험、환자년령、월경상태급종류림상병리특정적관계채용행x렬표X2검험;위험도비치비(OR)급95%가신구간(CI)운용비조건Logistic회귀분석계산.결과 (1)병례조중,CYP19기인rs4646(C/A)위점CC、AC、AA기인형적빈솔분별위47.6%、41.6%、10.7%,이대조조중칙분별위52.8%、38.3%、8.9%;병례조중,C、A등위기인적빈솔분별위68.5%、31.5%,이대조조중칙분별위71.9%、28.1%.이CC형위대조,AC、AA형몰유증가유선암적발생풍험(P>0.05),경년령분층,역미발현기여유선암역감성상관.(2)병례조중,CYP19기인rs1008805(A/G)위점종、AG、GG기인형적빈솔분별위44.6%、43.3%、12.0%,이대조조중칙분별위51.4%、40.2%、8.4%;병례조중,A、G등위기인적빈솔분별위66.3%、33.7%.이대조조중칙분별위71.5%、28.5%.이AA형위대조,AG、GG형몰유증가유선암적발생풍험(P>0.05),경년령분층,역미발현기여유선암역감성상관.(3)CYP19기인rs4646(CA/A)화rs1008805(X/G)다태성여유선암환자년령、월경상황급병리특정균무명현상관.결론 CYP19기인m4646、rs1008805다태성여유선암역감성무명현상관,상불추천단독작위미래유선암기인사사적후선지표.
Objective To investigate the effect of rs4646, and rs1008805 polymorphism in CYP19 gone on genetic susceptibility for breast cancer in Zhejiang population. Methods 233 breast canc-er patients and 180 healthy controls were involved in the study. Genotype analysis was performed through TaqMan assay. The odd ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional Logistic regression model. Results (1) The frequency of CC, AC, and AA genotype of rs4646 in case group and controls was 47.6%, 41.6%, 10.7% and 52.8% ,38.3%, 8.9%, respectively. The frequency of C,and A allele in case group and controls were 68.5%, 31.5% and 71.9%, 28.1%, respectively. No significant association was found between rs4646 polymorphism and breast cancer susceptibility. (2) The frequency of AA,AG,GG genotype of rs1008805 in case group and controls was 44.6%, 43.3%,12.0% and 51.4%, 40.2%, 8.4%, respectively. The frequency of A, and G allele in case group and controls was 66.3%, 33.7% and 71.5%, 28.5%, respectively. No significant association was found between rs1008805 polymorphism and breast cancer susceptibility. (3) No significant association was found be-tween rs4646, and rs1008805 polymorphism and pathological features. Conclusion There may be no rela-tionship between rs646,and rs1008805 polymorphism in CYPI9 gone and breast cancer susceptibility in Zhejiang population. Rs4646, and rs1008805 polymorphism in CYP19 may not be promising candidate lo-cus for breast cancer susceptibility in clinical genetic test.
