中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
2期
173-176
,共4页
高迁移率族蛋白质类/代谢%肝炎,乙型,慢性/代谢
高遷移率族蛋白質類/代謝%肝炎,乙型,慢性/代謝
고천이솔족단백질류/대사%간염,을형,만성/대사
High mobility group proteins/ME%Hepatitis B,chronic/ME
目的 研究晚期炎症介质高迁移率族蛋白-1(HMGB1)在慢性乙型肝炎、慢性重型乙型肝炎及乙肝肝硬化病程中的临床意义.方法 选择慢性乙型肝炎患者40例,慢性重型乙型肝炎患者18例,乙肝肝硬化患者18例,健康对照者20例,应用ELISA法检测血清HMGB1含量;同时检测各组患者肝功能生化指标、凝血酶原活动度(PTA)及肝纤维化指标.结果 HMGB1检出含量在乙型肝炎患者慢性重型肝炎组高于慢性肝炎组(P＜0.01),慢性肝炎组高于正常对照组(P＜0.01),肝硬化组与慢性重型肝炎组、慢性肝炎组之间差异有统计学意义(P＜0.01).HMGB1检出含量与外周血TBIL、AST/ALT、HA及PⅢNP均呈正相关(r=0.865,0.646,0.783,0.662,P＜0.01),与PTA及白蛋白水平呈负相关(r=-0.915,-0.852,P＜0.01).结论 乙肝相关性肝病患者血清HMGB1含量与其疾病严重程度密切相关,同时HMGB1也是辅助诊断肝纤维化的指标.
目的 研究晚期炎癥介質高遷移率族蛋白-1(HMGB1)在慢性乙型肝炎、慢性重型乙型肝炎及乙肝肝硬化病程中的臨床意義.方法 選擇慢性乙型肝炎患者40例,慢性重型乙型肝炎患者18例,乙肝肝硬化患者18例,健康對照者20例,應用ELISA法檢測血清HMGB1含量;同時檢測各組患者肝功能生化指標、凝血酶原活動度(PTA)及肝纖維化指標.結果 HMGB1檢齣含量在乙型肝炎患者慢性重型肝炎組高于慢性肝炎組(P＜0.01),慢性肝炎組高于正常對照組(P＜0.01),肝硬化組與慢性重型肝炎組、慢性肝炎組之間差異有統計學意義(P＜0.01).HMGB1檢齣含量與外週血TBIL、AST/ALT、HA及PⅢNP均呈正相關(r=0.865,0.646,0.783,0.662,P＜0.01),與PTA及白蛋白水平呈負相關(r=-0.915,-0.852,P＜0.01).結論 乙肝相關性肝病患者血清HMGB1含量與其疾病嚴重程度密切相關,同時HMGB1也是輔助診斷肝纖維化的指標.
목적 연구만기염증개질고천이솔족단백-1(HMGB1)재만성을형간염、만성중형을형간염급을간간경화병정중적림상의의.방법 선택만성을형간염환자40례,만성중형을형간염환자18례,을간간경화환자18례,건강대조자20례,응용ELISA법검측혈청HMGB1함량;동시검측각조환자간공능생화지표、응혈매원활동도(PTA)급간섬유화지표.결과 HMGB1검출함량재을형간염환자만성중형간염조고우만성간염조(P＜0.01),만성간염조고우정상대조조(P＜0.01),간경화조여만성중형간염조、만성간염조지간차이유통계학의의(P＜0.01).HMGB1검출함량여외주혈TBIL、AST/ALT、HA급PⅢNP균정정상관(r=0.865,0.646,0.783,0.662,P＜0.01),여PTA급백단백수평정부상관(r=-0.915,-0.852,P＜0.01).결론 을간상관성간병환자혈청HMGB1함량여기질병엄중정도밀절상관,동시HMGB1야시보조진단간섬유화적지표.
Objective To investigate the clinical significance of high mobility group box-1 protein (HMGB1) in chronic,severe hepatitis B patients and liver cirrhosis.Methods The contents of HMGB1 was measured by enzyme-linked immunoassay (ELISA) in the patients (include 40 patients with chronic hepatitis B and 18 severe hepatitis B patients and 18 liver cirrhosis patients) and 20 health controls.The levels of relative biochemical indicators,prothrombin time activity percentage (PTA) and the hepatic fibrosis were determined by biochemical methods.Results The contents of HMGB1 was significantly increased in severe hepatitis patients in comparison with that in chronic hepatitis B patients(P ＜0.01).The contents of HMGB1 in the chronic hepatitis were significantly increased in health controls(P ＜0.01).The contents of HMGB1 had significant difference among the liver cirrhosis patients,the severe hepatitis patients and the chronic hepatitis(P ＜0.01).There was positive correlation among the contents of HMGB1 and total bilirubin (TBIL),the proportionality of aspartate aminotransferase and alanine aminotransferase (AST/ALT),hyaluronic acid (HA) and procollagen Ⅲ N-terminal peptide (P Ⅲ NP) (r = 0.865,0.646,0.783,0.662,P ＜ 0.01).There was negative correlation among the contents of HMGB1 and prothrombin time activity percentage (PTA) and albumin (ALB) (r =-0.915,-0.852,P ＜0.01).Conclusion The contents of serum HMGB1 were closely associated with disease severity in chronic hepatitis B patients.HMGB1 was an index to auxiliary diagnosis hepatic fibrosis.
