CAJ | 학술논문

位于MHC内的肿瘤坏死因子（tomor necrosis factor，TNF）基因区域有5个微卫星基因座a、b、c、d和e，本研究调查了中国云南汉族系统性红斑狼疮（systemic lupus erythematosus,SLE）与这几个微卫星基因座多态性的关系。本文用荧光标记引物和半自动基因扫描方法对云南地区97例SLE患者及79例健康对照者的这5个微卫星基因座进行了基因分型，结果发现，SLE患者的TNFa1（P=0.0206）,c2(P=0.0000)等位基因频率较正常人显著增高，而TNFa2(P=0.0163),c3(P=0.0065),c4(P=0.0012),d6(P=0.0448)等位基因频率则是正常对照较SLE患者高。同时我们还发现在这5个微卫星基因座中，与白种人比较中国人出现了尚未发现的新等位基因。
위우MHC내적종류배사인자（tomor necrosis factor，TNF）기인구역유5개미위성기인좌a、b、c、d화e，본연구조사료중국운남한족계통성홍반랑창（systemic lupus erythematosus,SLE）여저궤개미위성기인좌다태성적관계。본문용형광표기인물화반자동기인소묘방법대운남지구97례SLE환자급79례건강대조자적저5개미위성기인좌진행료기인분형，결과발현，SLE환자적TNFa1（P=0.0206）,c2(P=0.0000)등위기인빈솔교정상인현저증고，이TNFa2(P=0.0163),c3(P=0.0065),c4(P=0.0012),d6(P=0.0448)등위기인빈솔칙시정상대조교SLE환자고。동시아문환발현재저5개미위성기인좌중，여백충인비교중국인출현료상미발현적신등위기인。
We have investigated TNF microsatellite polymorphism in SLE.A total of 97 Chinese Han SLE patients and 79 matched Chinese Han controls were studied in this study, TNF microsatellites a,b,c,d and e were typed using fluorescent labeled automated genescanning and genotyping.TNFa1（P=0.0206）,c2 (P=0.0000) allele frequencies were significantly increased in the SLE group comparing with controls,and TNF a2 (P=0.0163) c3(P=0.0065),c4(P=0.0012),d6(P=0.0448) allele frequencies were significantly increased in controls.Meanwhile,we found some new alleles in Chinese which are different form those in Caucasoids.