CAJ | 학술논문

目的比较2型糖尿病(T2DM)与急性冠脉综合征(ACS)患者缺血修饰性白蛋白(IMA)水平,探讨DM并发症可能机制和病理过程. 方法利用血清白蛋白结合重金属钴的能力随IMA增加而下降的特性,480nm波长连续监测反应体系中游离钴,以游离钴显色率和吸光度单位报告结果. 结果对照组与ACS组和DM组比较以及DM组与ACS组比较具有极显著性差异(P<0.001). 结论血清白蛋白结合钴实验不仅是评价急性心肌缺血的指标,对T2DM并发症的早期监测和预防也具有重要意义.
목적 비교2형당뇨병(T2DM)여급성관맥종합정(ACS)환자결혈수식성백단백(IMA)수평,탐토DM병발증가능궤제화병리과정. 방법 이용혈청백단백결합중금속고적능력수IMA증가이하강적특성,480nm파장련속감측반응체계중유리고,이유리고현색솔화흡광도단위보고결과. 결과 대조조여ACS조화DM조비교이급DM조여ACS조비교구유겁현저성차이(P<0.001). 결론 혈청백단백결합고실험불부시평개급성심기결혈적지표,대T2DM병발증적조기감측화예방야구유중요의의.
Objective To compare the ischemia-modified albumin(IMA)level between T2DM and AMI,and to discuss the possible mechanism and pathology process.Methods According to the decrease of power of albumin binding cobalt along with the increase of ischemia-modified albumin,the automated continuous detection of free cobalt in reactive system were conducted using the 480nm wavelength and the results were reported as absorbance unit(ABSU)and coloration rate of free cobalt.Results There were significant differences in serum free cobalt between the control and groups of acute coronary syndrome(ACS)and type 2 diabetes and between ACS and type 2 diabetes(P<0.001).Conclusions Albumin-binding cobalt test can be regarded as effective biochemical index for evaluating acute myocardial ischemia,and it can be used to monitor and prevent the early complication of T2DM