国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
1期
11-13
,共3页
乳腺肿瘤%血管内皮生长因子C%血管内皮生长因子受体3
乳腺腫瘤%血管內皮生長因子C%血管內皮生長因子受體3
유선종류%혈관내피생장인자C%혈관내피생장인자수체3
Breast neoplasms%Vascular endothelial growth factor C%Vascular endothelial growth factor receptor-3
目的 探讨血管内皮细胞生长因子VEGF-C及其受体VEGFR-3在乳腺癌组织中的表达与腋淋巴结转移之间的关系.方法 应用免疫组化法检测58例乳腺癌组织标本及10例癌旁对照组织VEGF-C、VEGFR-3的表达,并在淋巴结转移和未转移组间比较其差异.结果 VEGF-C和VEGFR-3在乳腺癌腋淋巴结转移组的阳性率分别为87.5%和83.3%,明显高于非转移组的表达(55.9%和38.2%);VEGFR-3阳性脉管数在淋巴结转移组(8.54±2.54)明显高于淋巴结非转移组(4.73±2.46).结论 乳腺癌组织VEGF-C和VEGFR-3的表达明显增强,并与淋巴结转移密切相关,该信号系统可能成为抗某些肿瘤淋巴道转移的特异性靶标.
目的 探討血管內皮細胞生長因子VEGF-C及其受體VEGFR-3在乳腺癌組織中的錶達與腋淋巴結轉移之間的關繫.方法 應用免疫組化法檢測58例乳腺癌組織標本及10例癌徬對照組織VEGF-C、VEGFR-3的錶達,併在淋巴結轉移和未轉移組間比較其差異.結果 VEGF-C和VEGFR-3在乳腺癌腋淋巴結轉移組的暘性率分彆為87.5%和83.3%,明顯高于非轉移組的錶達(55.9%和38.2%);VEGFR-3暘性脈管數在淋巴結轉移組(8.54±2.54)明顯高于淋巴結非轉移組(4.73±2.46).結論 乳腺癌組織VEGF-C和VEGFR-3的錶達明顯增彊,併與淋巴結轉移密切相關,該信號繫統可能成為抗某些腫瘤淋巴道轉移的特異性靶標.
목적 탐토혈관내피세포생장인자VEGF-C급기수체VEGFR-3재유선암조직중적표체여액림파결전이지간적관계.방법 응용면역조화법검측58례유선암조직표본급10례암방대조조직VEGF-C、VEGFR-3적표체,병재림파결전이화미전이조간비교기차이.결과 VEGF-C화VEGFR-3재유선암액림파결전이조적양성솔분별위87.5%화83.3%,명현고우비전이조적표체(55.9%화38.2%);VEGFR-3양성맥관수재림파결전이조(8.54±2.54)명현고우림파결비전이조(4.73±2.46).결론 유선암조직VEGF-C화VEGFR-3적표체명현증강,병여림파결전이밀절상관,해신호계통가능성위항모사종류림파도전이적특이성파표.
Objective To investigate the expression of vascular endothelial cell growth factor-C (VEGF-C) and its receptor--vascular endothelial cell growth factor receptor-3 (VEGFR-3) in breast cancer tissue and its correlation with metastasis of lymphonodi axillares.Methods Fifty-eight cases of breast cancer samples and 10 cases of tumor adjacent non-carcinomatous tissue were measured by immunohistochemical staining for expression of VEGF-C and VEGFR-3. Their expression rates were compared between axillary lymph node metastasis and non-metastasis groups.Results The positive rates of VEGF-C and VEGFR-3 as well as the number of VEGFR-3 positive vessels were significantly higher than those in lymph node non-metastasis group (87.5% vs 55.9%; 83.3% vs 38.2%; 8.54±2.54 vs 4.73±2.46, respectively).Conclusion The high expression of VEGF-C and VEGFR-3 as well as the increase in the number of VEGFR-3 positive vessels are related to lymph node metastasis of human breast cancer. VEGF-C/VEGFR-3 system may be a new specific target which contributes to blockage of lymphatic metastasis in breast cancer.
