CAJ | 학술논문

目的改进<中华人民共和国药典>2005年版中蓼科植物何首乌及其饮片的薄层鉴别方法,增订检查项.方法改变原有的薄层展开剂,用氯仿-甲醇展开系统代替毒性较大的苯-乙醇展开系统.按照2005版药典附录方法增订水分、灰分及浸出物检查等.结果何首乌及其饮片的薄层鉴别方法改为氯仿一甲醇展开系统,2次展开,能得到满意结果;制定的水分、总灰分、酸不溶性灰分及浸出物的限度范围被复核单位验证认可.结论该展开系统具有毒性较低的优点,可以作为何首乌及其炮制品的薄层鉴别方法.增加了总灰分,酸不溶性灰分,水分及浸出物的检查,并制定了相关限度,更能全面地控制药品质量.
목적 개진<중화인민공화국약전>2005년판중료과식물하수오급기음편적박층감별방법,증정검사항.방법 개변원유적박층전개제,용록방-갑순전개계통대체독성교대적분-을순전개계통.안조2005판약전부록방법증정수분、회분급침출물검사등.결과 하수오급기음편적박층감별방법개위록방일갑순전개계통,2차전개,능득도만의결과;제정적수분、총회분、산불용성회분급침출물적한도범위피복핵단위험증인가.결론 해전개계통구유독성교저적우점,가이작위하수오급기포제품적박층감별방법.증가료총회분,산불용성회분,수분급침출물적검사,병제정료상관한도,경능전면지공제약품질량.
Objective To modify the differentiation method of TCL for Heshouwu(Radix Polygoni multiflori)and its decoction pieces in Pharmacopoeia of the People's Republic of China(Edition 2005)and enlarge the examination items.Method The original TCL developing agent was changed and the TLC developing system of benzene-alcohol was replaced by the TLC developing system of chloroform-methanol.The examinations of moisture,ash and extract were revised and enlarged according to the method in the Appendix of Pharmacopoeia of the People's Republic of China (Edition 2005).Result The differentiation method of TCL for Heshouwu was revised to the TLG developing system of chloroform-methanol and a satisfactory result was obtained after two times of development.The limit for the moisture,total ash,acid-insoluble ash and extract made in this study wag approved by the unit of validation and verification.Conclusion The TLC developing system of chloroform-methanol has the characteristic of lower toxicity and can be used in the differentiation method of rlEL for Heshouwu.The relevant limit and examination of the moisture,total ash,acid-insoluble ash and extract are added for control the quality of Heshouwu totally.