中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2010年
15期
2823-2827
,共5页
冯洁%刘铭%张建佚%万钢%齐科研%郑陈光%吕泽平%胡才有%杨泽
馮潔%劉銘%張建佚%萬鋼%齊科研%鄭陳光%呂澤平%鬍纔有%楊澤
풍길%류명%장건일%만강%제과연%정진광%려택평%호재유%양택
长寿%线粒体基因变异%载脂蛋白E%多聚酶链反应-限制性片段长度多态性%基因多态性%关联分析
長壽%線粒體基因變異%載脂蛋白E%多聚酶鏈反應-限製性片段長度多態性%基因多態性%關聯分析
장수%선립체기인변이%재지단백E%다취매련반응-한제성편단장도다태성%기인다태성%관련분석
背景:有研究表明线粒体基因变异与长寿相关,但在中国南方群体中线粒体单倍组D及其亚组与长寿的相关性研究至今少有报道,并且线粒体单倍组D及其亚组与载脂蛋白E基因相互作用对长寿的影响未见报道.目的:探讨在中国南方群体中线粒体单倍组D及其亚组与长寿的相关性,以及线粒体单倍组D及其亚组与载脂蛋白E基因的相互作用.方法:于2007/2008在广西壮族自治区巴马县选取对象1 038人,包括长寿组367人(年龄>90岁)和与长寿组无亲缘关系的当地健康对照组671人(年龄40~60岁).采用多聚酶链反应-限制性片段长度多态性技术检测线粒体单倍组D及其亚组(D4和D4a)的分布情况,并通过分层分析调整性别和载脂蛋白E基因混杂因素的作用.结果与结论:线粒体单倍组D及其亚组与长寿无明显相关性(P>0.05).按照性别进行分层分析后,在女性和男性群体中仍未发现线粒体单倍组D及其亚组与长寿的关联(P>0.05).然而,对载脂蛋白E基因分层分析后,在载脂蛋白E 携带者中长寿组和对照组线粒体单倍组D的分布频率差异有显著性意义(P<0.05).结果提示线粒体单倍组D可能是与载脂蛋白E基因的相互作用对长寿产生影响.
揹景:有研究錶明線粒體基因變異與長壽相關,但在中國南方群體中線粒體單倍組D及其亞組與長壽的相關性研究至今少有報道,併且線粒體單倍組D及其亞組與載脂蛋白E基因相互作用對長壽的影響未見報道.目的:探討在中國南方群體中線粒體單倍組D及其亞組與長壽的相關性,以及線粒體單倍組D及其亞組與載脂蛋白E基因的相互作用.方法:于2007/2008在廣西壯族自治區巴馬縣選取對象1 038人,包括長壽組367人(年齡>90歲)和與長壽組無親緣關繫的噹地健康對照組671人(年齡40~60歲).採用多聚酶鏈反應-限製性片段長度多態性技術檢測線粒體單倍組D及其亞組(D4和D4a)的分佈情況,併通過分層分析調整性彆和載脂蛋白E基因混雜因素的作用.結果與結論:線粒體單倍組D及其亞組與長壽無明顯相關性(P>0.05).按照性彆進行分層分析後,在女性和男性群體中仍未髮現線粒體單倍組D及其亞組與長壽的關聯(P>0.05).然而,對載脂蛋白E基因分層分析後,在載脂蛋白E 攜帶者中長壽組和對照組線粒體單倍組D的分佈頻率差異有顯著性意義(P<0.05).結果提示線粒體單倍組D可能是與載脂蛋白E基因的相互作用對長壽產生影響.
배경:유연구표명선립체기인변이여장수상관,단재중국남방군체중선립체단배조D급기아조여장수적상관성연구지금소유보도,병차선립체단배조D급기아조여재지단백E기인상호작용대장수적영향미견보도.목적:탐토재중국남방군체중선립체단배조D급기아조여장수적상관성,이급선립체단배조D급기아조여재지단백E기인적상호작용.방법:우2007/2008재엄서장족자치구파마현선취대상1 038인,포괄장수조367인(년령>90세)화여장수조무친연관계적당지건강대조조671인(년령40~60세).채용다취매련반응-한제성편단장도다태성기술검측선립체단배조D급기아조(D4화D4a)적분포정황,병통과분층분석조정성별화재지단백E기인혼잡인소적작용.결과여결론:선립체단배조D급기아조여장수무명현상관성(P>0.05).안조성별진행분층분석후,재녀성화남성군체중잉미발현선립체단배조D급기아조여장수적관련(P>0.05).연이,대재지단백E기인분층분석후,재재지단백E 휴대자중장수조화대조조선립체단배조D적분포빈솔차이유현저성의의(P<0.05).결과제시선립체단배조D가능시여재지단백E기인적상호작용대장수산생영향.
BACKGROUND:MtDNA haplogroup D has been shown to influence longevity trait. However,the effects that mtDNA haplogroup D (and its subhaplogroups) have upon longevity in Southern Chinese population have rarely been reported,and the effect of reaction of mtDNA haplogroup D (and its subhaplogroup) and apolipoprotein E(APOE) gene on longevity remains poorly understood.OBJECTIVE:To explore the association between mtDNA haplogroup D(and its subhaplogroup) and longevity in southern Chinese population,and the interaction of mtDNA haplogroup D(and its subhaplogroup) with APOE gene.METHODS:A total of 1 038 people were selected from Bama,Guangxi between 2007 and 2008.including 367 long-lived individuals (aged>90 years) and 671 local and unrelated younger controls (aged 40-60 years).Using polymerase chain reaction-restriction fragment length polymorphism,the distribution of mtDNA haplogroup D and its subhaplogroup(D4,D4a) was tested.The confounding effect of gender and APOE gene was detected by stratification analysis.RESULTS AND CONCLUSION:There was no significant correlation between mtDNA haplogroup D (and its subhaplogroup) and longevity (P>0.05).Stratification analysis by gender showed no significant difference for frequencies distribution of mtDNA haplogroup D and its subhaplogroup(D4,D4a)between long-lived individuals and controls in women and men (P>0.05).However,the frequency distribution of mtDNA haplogroups D was different between long-lived individuals and controls with APOE .05) through stratification analysis by APOE gene.Results show that mDNA haplogroup D may affect longevity by interacting with APOE gene.