国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2008年
12期
729-732
,共4页
杜昀泽%刘林林%纪凤祥%董万军%刘喜梅
杜昀澤%劉林林%紀鳳祥%董萬軍%劉喜梅
두윤택%류림림%기봉상%동만군%류희매
肿瘤坏死因子α基因%多态性%慢性阻塞性肺疾病
腫瘤壞死因子α基因%多態性%慢性阻塞性肺疾病
종류배사인자α기인%다태성%만성조새성폐질병
Tumor necrosis factor-α gene%Polymorphisms%Chronic obstructive pulmonary disease
目的 探讨肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)+489基因多态性与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)易感性的关系.方法 用聚合酶链反应-限制性片段长度多态性技术对55例COPD患者、47例对照组(性别、年龄和吸烟史配对)和55名健康查体组的TNF-α+489G/A基因多态性进行检测,并对其易感性进行分析.结果 COPD组、对照组及健康查体组携带GA/AA基因型的发生率分别为23.6%、14.3%和9.1%,3组间差异无统计学意义(P＞0.05).当COPD组与健康查体组比较,携带等位基因A的人群更易发生COPD(P＜0.05).COPD组携带GA/AA基因型患者肺源性心脏病的发病率明显高于携带GG基因型的患者(P＜0.05).结论 在TNF-α+489位点上携带等位基因A的人群可能是发生COPD的一个高危因素,且预后不佳.
目的 探討腫瘤壞死因子α(tumor necrosis factor-α,TNF-α)+489基因多態性與慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)易感性的關繫.方法 用聚閤酶鏈反應-限製性片段長度多態性技術對55例COPD患者、47例對照組(性彆、年齡和吸煙史配對)和55名健康查體組的TNF-α+489G/A基因多態性進行檢測,併對其易感性進行分析.結果 COPD組、對照組及健康查體組攜帶GA/AA基因型的髮生率分彆為23.6%、14.3%和9.1%,3組間差異無統計學意義(P＞0.05).噹COPD組與健康查體組比較,攜帶等位基因A的人群更易髮生COPD(P＜0.05).COPD組攜帶GA/AA基因型患者肺源性心髒病的髮病率明顯高于攜帶GG基因型的患者(P＜0.05).結論 在TNF-α+489位點上攜帶等位基因A的人群可能是髮生COPD的一箇高危因素,且預後不佳.
목적 탐토종류배사인자α(tumor necrosis factor-α,TNF-α)+489기인다태성여만성조새성폐질병(chronic obstructive pulmonary disease,COPD)역감성적관계.방법 용취합매련반응-한제성편단장도다태성기술대55례COPD환자、47례대조조(성별、년령화흡연사배대)화55명건강사체조적TNF-α+489G/A기인다태성진행검측,병대기역감성진행분석.결과 COPD조、대조조급건강사체조휴대GA/AA기인형적발생솔분별위23.6%、14.3%화9.1%,3조간차이무통계학의의(P＞0.05).당COPD조여건강사체조비교,휴대등위기인A적인군경역발생COPD(P＜0.05).COPD조휴대GA/AA기인형환자폐원성심장병적발병솔명현고우휴대GG기인형적환자(P＜0.05).결론 재TNF-α+489위점상휴대등위기인A적인군가능시발생COPD적일개고위인소,차예후불가.
Objective To study the relationship between tumor necrosis factor-α+489G/A gene polymorphisms and susceptibility to development of chronic obstructive pulmonary disease(COPD).Methods Polymerase chain reaction-restriction fragment length polymorphism method was used to detect the polymorphism of TNF-α+489G/A gene in 5 5 cases of COPD,47 cases of sex,age and smoke history matched controls and 55 cases of body-check healthy subjects and their susceptibility to development of COPD was analyzed.Results The frequencies of GA/AA genotype in COPD group,control group and body-check healthy group were 23.6%,14.3%and 9.1%,respectively.There were not statistic difference between the groups(P＞0.05).Statistical analysis showed that COPD group had a significantly higher allele A frequency than that of body-check healthy group(P＜0.05).The prevalence of chronic pulmonary heart disease in the GA/AA genotype was higher than the GG genotype in COPD group.Conclusions The peoples who carry allele A in TNF-α+489 may increase the risk of COPD and poor progress.
