CAJ | 학술논문

血吸虫病肝纤维化是以胶原蛋白为主的细胞外基质(extracellular matrix,ECM)的合成与降解失衡导致胶原过度沉积的结果,其纤维化过程主要是由多条信号转导途径和一系列的细胞因子网络共同调控的.近几年国内外研究发现白细胞介素-13(interleukin-13,IL-13)在血吸虫病肝纤维化形成和发展过程中起着重要作用.白细胞介素-13受体α1(interleukin-13 receptorα1,IL-13Rα1)作为IL-13功能受体,在肝星状细胞(hapatic stellate cells,HSC)膜表面起促纤维化作用,而IL-13Rα2作为IL-13诱饵受体(decoy receptor),起抑制纤维化的作用.此外,IL-13还可通过替代激活途径激活巨噬细胞发挥促纤维化作用.总之,IL-13及其受体与血吸虫病肝纤维化关系的研究目前已成为热点之一.该文就IL-13及其受体在血吸虫病肝纤维化中作用的最新研究进展做一综述.
혈흡충병간섬유화시이효원단백위주적세포외기질(extracellular matrix,ECM)적합성여강해실형도치효원과도침적적결과,기섬유화과정주요시유다조신호전도도경화일계렬적세포인자망락공동조공적.근궤년국내외연구발현백세포개소-13(interleukin-13,IL-13)재혈흡충병간섬유화형성화발전과정중기착중요작용.백세포개소-13수체α1(interleukin-13 receptorα1,IL-13Rα1)작위IL-13공능수체,재간성상세포(hapatic stellate cells,HSC)막표면기촉섬유화작용,이IL-13Rα2작위IL-13유이수체(decoy receptor),기억제섬유화적작용.차외,IL-13환가통과체대격활도경격활거서세포발휘촉섬유화작용.총지,IL-13급기수체여혈흡충병간섬유화관계적연구목전이성위열점지일.해문취IL-13급기수체재혈흡충병간섬유화중작용적최신연구진전주일종술.
Hepatic fibrosis results from an imbalance between fibrogenesis and fibrolysis,which leads to fibroproliferation and deposition of extracellular matrix components in liver. Hepatic fibrosis is probably regulated by several cell signal transduction pathways and a range of cytokines. Numerous reports on the molecular mechanism of hepatic fibrosis indicated that IL-13 ,working together with IL-13 receptor α1 (IL-13Rα1) which is membrane receptor in hepatic stellate cells, plays a key promotion role and IL-13 receptor α2(IL-13Rα2)acts as a decoy receptor. In addition, IL-13 can alternatively activate macrophages to promote fibosis. This review focused on the effects of IL-13 and its receptors on the formation of eggs granuloma and hepatic fibrosis in schistosomiasis.