缬沙坦对糖尿病大鼠动脉Toll样受体4和髓样分化因子88表达的影响
힐사탄대당뇨병대서동맥Toll양수체4화수양분화인자88표체적영향
Effect of valsartan on the expressions of Toll-like receptor 4 and myeloid differentiation factor 88 in the arteries of diabetic rats
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2009年 4期 378-381 ,共4页

    吴珺%游娜%徐家蓉%左志华%胡爱平%蒋秀琴%缪珩%鲁一兵

    오군%유나%서가용%좌지화%호애평%장수금%무형%로일병

    糖尿病,实验性%大鼠,Sprague-Dawley%动脉血管组织%Toll样受体4%髓样分化因子88%缬沙坦 糖尿病,實驗性%大鼠,Sprague-Dawley%動脈血管組織%Toll樣受體4%髓樣分化因子88%纈沙坦
    당뇨병,실험성%대서,Sprague-Dawley%동맥혈관조직%Toll양수체4%수양분화인자88%힐사탄
    Diabetes mellitus,experimental%Rats,Sprague-Dawley%Arteria%Toll-like receptor 4%Myeloid differentiation factor 88%Valsartan
    P<0.01),糖尿病和缬沙坦组间血糖差异无统计学意义(P>0.05);糖尿病组大鼠血管组织中TLR4和Myd88 mRNA与蛋白的表达明显高于正常对照组(均P<0.01),而缬沙坦组明显低于糖尿病组(均P<0.01).结论 缬沙坦降低糖尿病大鼠动脉血管组织中TLR4和Myd88表达,可能对糖尿病血管早期的炎性改变起防治作用.
    P<0.01),당뇨병화힐사탄조간혈당차이무통계학의의(P>0.05);당뇨병조대서혈관조직중TLR4화Myd88 mRNA여단백적표체명현고우정상대조조(균P<0.01),이힐사탄조명현저우당뇨병조(균P<0.01).결론 힐사탄강저당뇨병대서동맥혈관조직중TLR4화Myd88표체,가능대당뇨병혈관조기적염성개변기방치작용.
    ay be useful for preventing or treating early inflammation in the arteria of diabetic rats.
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