CAJ | 학술논문

目的探讨索利那新加坦索罗辛治疗膀胱过度活动症(OAB)的疗效.方法 OAB患者53例,男15例,女38例.年龄29～72岁,平均43岁.随机分为2组,A组为单用索利那新组(27例),B组为索利那新加用坦索罗辛组(26例).服药方法:索利那新5 mg/d,坦索罗辛0.2 mg/d.连续14 d后随访,再进行OABSS评分.结果 A组患者治疗前后尿急评分分别为(3.3±1.0)与(1.9±0.6)分,OABSS评分分别为(10.8±4.9)与(5.2±1.8)分;B组患者治疗前后尿急评分分别为(3.6±1.0)与(0.9±0.1)分,OABSS评分分别为(10.7±1.9)与(3.9±1.8)分,2组治疗前后差异均有统计学意义(P＜0.05),2组治疗后尿急评分和OABSS评分差异有统计学意义(P＜0.05).结论索利那新加用坦索罗辛可以有效缓解OAB患者的尿急症状并降低OABSS评分,索利那新加用坦索罗辛疗效好于单用索利那新.
목적 탐토색리나신가탄색라신치료방광과도활동증(OAB)적료효.방법 OAB환자53례,남15례,녀38례.년령29～72세,평균43세.수궤분위2조,A조위단용색리나신조(27례),B조위색리나신가용탄색라신조(26례).복약방법:색리나신5 mg/d,탄색라신0.2 mg/d.련속14 d후수방,재진행OABSS평분.결과 A조환자치료전후뇨급평분분별위(3.3±1.0)여(1.9±0.6)분,OABSS평분분별위(10.8±4.9)여(5.2±1.8)분;B조환자치료전후뇨급평분분별위(3.6±1.0)여(0.9±0.1)분,OABSS평분분별위(10.7±1.9)여(3.9±1.8)분,2조치료전후차이균유통계학의의(P＜0.05),2조치료후뇨급평분화OABSS평분차이유통계학의의(P＜0.05).결론 색리나신가용탄색라신가이유효완해OAB환자적뇨급증상병강저OABSS평분,색리나신가용탄색라신료효호우단용색리나신.
Objective To evaluate the efficacy of solifenacin with or without tamsulosin in patients with overactive bladder (OAB).Methods Fifty-three patients with OAB were randomly divided into two groups (group A 27 patients, group B 26 patients).The patients received either solifenacin 5 mg/day in group A or combined with Tamsulosin 0.2 mg/day in group B for two weeks.During the treatent period all the patients recorded voiding and adverse events in a diary.The symptoms of urgency, frequency, incontinence were evaluated by OABSS scores at the begining and end of the therapy period.The results of the efficacy and safety were analyzed by using SPSS 13.0.Results The OABSS scores at the begining and end for the two groups were significantly different ( P ＜ 0.01 ).In both groups the efficacy was obvious.The OABSS scores at the end of the therapy between group A and B were significantly different (P ＜0.05 ).The efficacy of group B was better than that of group A.Conclusion The efficacy of solifenacin combined with tamsulosin was better than solifenacin alone in OAB.