中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2011年
3期
210-213
,共4页
鲁晓擘%刘浩%徐琴%张跃新%邓泽润%胡安华%刘文杰%吕荣福
魯曉擘%劉浩%徐琴%張躍新%鄧澤潤%鬍安華%劉文傑%呂榮福
로효벽%류호%서금%장약신%산택윤%호안화%류문걸%려영복
黄疸,慢性特发性%肝炎,乙型,慢性%肝细胞%脂褐素小体
黃疸,慢性特髮性%肝炎,乙型,慢性%肝細胞%脂褐素小體
황달,만성특발성%간염,을형,만성%간세포%지갈소소체
Jaundice,chronic idiopathic%Hepatitis B,chronic%Hepatocytes%Myelin-like bodies
目的 研究Dubin-Johnson综合征合并慢性乙型肝炎患者肝细胞脂褐素小体的超微结构特点.方法用透射电子显微镜(简称电镜)对11例Dubin-Johnson综合征合并慢性乙型肝炎(轻度)患者、5例Dubin-Johnson综合征患者的肝细胞超微结构进行观察,重点观察脂褐素小体的形态及密度.对数据的统计学分析采用Fisher's精确概率法.结果 11例Dubin-Johnson综合征合并慢性乙型肝炎(轻度)患者的肝细胞脂褐素小体形态呈现多形性,电镜下至少有5种形态:"明亮型"(18.2%,2/11)、"网眼型"(9.1%,1/11)、"点状型"(54.5%,6/11)、"不规则型"(9.1%,1/11)和"基本型"(9.1%,1/11);而未合并慢性乙型肝炎的Dubin-Johnson综合征患者的肝细胞脂褐素小体形态相对较为单一,为"基本型"(100.0%,5/5)."基本型"的差异在两组间比较,P=0.0013.两组患者脂褐素小体的密度也不均等,合并慢性乙型肝炎(轻度)患者的肝细胞脂褐素小体密度低,未合并慢性乙型肝炎(轻度)的Dubin-Johnson综合征患者肝细胞脂褐素小体密度高.结论 Dubin-Johnson综合征合并慢性乙型肝炎(轻度)患者肝细胞脂褐素小体形态呈现多形性,含高电子密度物质的比例少;而Dubin-Johnson综合征患者的肝细胞脂褐素小体形态相对较为单一,以色素沉着较重的"基本型"为主,含高电子密度物质的比例多.二者的差别在诊断上可能有一定价值.
目的 研究Dubin-Johnson綜閤徵閤併慢性乙型肝炎患者肝細胞脂褐素小體的超微結構特點.方法用透射電子顯微鏡(簡稱電鏡)對11例Dubin-Johnson綜閤徵閤併慢性乙型肝炎(輕度)患者、5例Dubin-Johnson綜閤徵患者的肝細胞超微結構進行觀察,重點觀察脂褐素小體的形態及密度.對數據的統計學分析採用Fisher's精確概率法.結果 11例Dubin-Johnson綜閤徵閤併慢性乙型肝炎(輕度)患者的肝細胞脂褐素小體形態呈現多形性,電鏡下至少有5種形態:"明亮型"(18.2%,2/11)、"網眼型"(9.1%,1/11)、"點狀型"(54.5%,6/11)、"不規則型"(9.1%,1/11)和"基本型"(9.1%,1/11);而未閤併慢性乙型肝炎的Dubin-Johnson綜閤徵患者的肝細胞脂褐素小體形態相對較為單一,為"基本型"(100.0%,5/5)."基本型"的差異在兩組間比較,P=0.0013.兩組患者脂褐素小體的密度也不均等,閤併慢性乙型肝炎(輕度)患者的肝細胞脂褐素小體密度低,未閤併慢性乙型肝炎(輕度)的Dubin-Johnson綜閤徵患者肝細胞脂褐素小體密度高.結論 Dubin-Johnson綜閤徵閤併慢性乙型肝炎(輕度)患者肝細胞脂褐素小體形態呈現多形性,含高電子密度物質的比例少;而Dubin-Johnson綜閤徵患者的肝細胞脂褐素小體形態相對較為單一,以色素沉著較重的"基本型"為主,含高電子密度物質的比例多.二者的差彆在診斷上可能有一定價值.
목적 연구Dubin-Johnson종합정합병만성을형간염환자간세포지갈소소체적초미결구특점.방법용투사전자현미경(간칭전경)대11례Dubin-Johnson종합정합병만성을형간염(경도)환자、5례Dubin-Johnson종합정환자적간세포초미결구진행관찰,중점관찰지갈소소체적형태급밀도.대수거적통계학분석채용Fisher's정학개솔법.결과 11례Dubin-Johnson종합정합병만성을형간염(경도)환자적간세포지갈소소체형태정현다형성,전경하지소유5충형태:"명량형"(18.2%,2/11)、"망안형"(9.1%,1/11)、"점상형"(54.5%,6/11)、"불규칙형"(9.1%,1/11)화"기본형"(9.1%,1/11);이미합병만성을형간염적Dubin-Johnson종합정환자적간세포지갈소소체형태상대교위단일,위"기본형"(100.0%,5/5)."기본형"적차이재량조간비교,P=0.0013.량조환자지갈소소체적밀도야불균등,합병만성을형간염(경도)환자적간세포지갈소소체밀도저,미합병만성을형간염(경도)적Dubin-Johnson종합정환자간세포지갈소소체밀도고.결론 Dubin-Johnson종합정합병만성을형간염(경도)환자간세포지갈소소체형태정현다형성,함고전자밀도물질적비례소;이Dubin-Johnson종합정환자적간세포지갈소소체형태상대교위단일,이색소침착교중적"기본형"위주,함고전자밀도물질적비례다.이자적차별재진단상가능유일정개치.
Objective To explore characteristics of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome (DJS) complicated with chronic hepatitis B (CHB). Methods 11 cases of DJS complicated with CHB and 5 cases DJS without CHB were studied clinicopathologically. The hepatocyte ultrastructure was observed with transmission electron microscope and taken photos. The data were compared and analyzed using Fisher's Exact Test. Results Deposition of myelin-like bodies can be observed in the hepatocytes of DJS patients with CHB but can not in DJS patients without CHB. The morphology of pigment varys. The electron density and volume of pigment in DJS patients with CHB can be classified into five types: brights (2/11,18.2%), reticulation (1/11, 9.1%), punctiform (6/11, 54.5%), abnormiry (1 / 11, 9.1%) and primary type (1 / 11, 9.1%). The myelin-like bodies in the hepatocytes of patients with DJS are high density and round with membrance (we named it as primary type) (5/5, 100%). Conclusions The myelin-like bodies in the hepatocytes of DJS patients with CHB possess special pleomorphism and may have important diagnostic value.