CAJ | 학술논문

目的调查广西壮族自治区孕妇、患病新生儿、肾病患者、肾移植患者及正常体检者尿中人巨细胞病毒阳性率,了解人类巨细胞病毒在广西不同人群中的分布情况,初步探讨人巨细胞病毒感染与肾脏疾病的关系.方法用荧光定量PCR检测研究对象晨尿中人巨细胞病毒DNA.结果孕妇、患病新生儿、肾病者、肾移植患者及正常体检者尿中人巨细胞病毒DNA阳性率依次为8.18%、3.45%、18.54%、25.42%、0.56%,其在各类肾病患者中的感染率均在10%左右,尤其在狼疮肾炎患者中的感染率更是达到27.78%.结论人巨细胞病毒在黄疸和早产新生儿中的感染率均较高,需要加强母婴人巨细胞病毒感染的防控工作.人巨细胞病毒很可能在肾病患者发病时对患者肾脏造成损害,并且加重肾病患者的病情,成为肾衰的一个诱因.
목적 조사엄서장족자치구잉부、환병신생인、신병환자、신이식환자급정상체검자뇨중인거세포병독양성솔,료해인류거세포병독재엄서불동인군중적분포정황,초보탐토인거세포병독감염여신장질병적관계.방법 용형광정량PCR검측연구대상신뇨중인거세포병독DNA.결과 잉부、환병신생인、신병자、신이식환자급정상체검자뇨중인거세포병독DNA양성솔의차위8.18%、3.45%、18.54%、25.42%、0.56%,기재각류신병환자중적감염솔균재10%좌우,우기재랑창신염환자중적감염솔경시체도27.78%.결론 인거세포병독재황달화조산신생인중적감염솔균교고,수요가강모영인거세포병독감염적방공공작.인거세포병독흔가능재신병환자발병시대환자신장조성손해,병차가중신병환자적병정,성위신쇠적일개유인.
Objective To detect Human Cytomegalovirus (HCMV) DNA in urine samples from the following groups:pregnant women,sick newborns,hospitalized nephropathy patients,renal transplant recipients and normal population.Preliminarily study the relationship of HCMVinfection and renal disease.Methods To detect HCMV DNA in morning urine samples by Real-time fluorescence quantitative PCR (FQ-PCR).Results The positive rates of HCMV DNA in the urine of pregnant women,sick newborns,hospitalized nephropathy patients,renal transplant recipients and normal population are 8.1 8%,3.45%,18.54%,25.42%,0.56%.Conclusion The infection rates of HCMV in the urine of pregnant women and sick newborns are very high in Guangxi,it should take serious measures to prevent and control the situation.HCMV probably participate in the iniury of kidney,and worsen the disease.It should be one of the causes of renal disease.