CAJ | 학술논문

目的探讨直肠异常隐窝病灶(ACF)对大肠癌及进展型腺瘤的预警作用,并分析其危险因素.方法应用独立样本t检验、单向方差分析及卡方检验分析比较直肠ACF的均数及发病率,应用Logistic回归分析直肠ACF与大肠癌及进展型腺瘤的关系,观察是否有预警作用,并筛选对ACF有显著意义的危险因素.结果 5个以上ACF显著增加大肠癌及进展型腺瘤的风险(P＜0.05);高龄和吸烟为ACF的危险因素,而阿司匹林的应用为其保护因素.结论 5个以上ACF对大肠癌及进展型腺瘤有显著预警作用.在大肠癌的早期预防中,我们应该重视对ACF的形成有意义的影响因素.
목적 탐토직장이상은와병조(ACF)대대장암급진전형선류적예경작용,병분석기위험인소.방법 응용독립양본t검험、단향방차분석급잡방검험분석비교직장ACF적균수급발병솔,응용Logistic회귀분석직장ACF여대장암급진전형선류적관계,관찰시부유예경작용,병사선대ACF유현저의의적위험인소.결과 5개이상ACF현저증가대장암급진전형선류적풍험(P＜0.05);고령화흡연위ACF적위험인소,이아사필림적응용위기보호인소.결론 5개이상ACF대대장암급진전형선류유현저예경작용.재대장암적조기예방중,아문응해중시대ACF적형성유의의적영향인소.
Objective To investigate the predictive value of rectal aberrant crypt foci(ACF)for colorectal cancer(CRC)and progressive adenomas, and to analyze its risk factors.Methods IndependentSample T test, One-Way ANOVA and Chi-square test were used to analyze the mean number and incidence of rectal ACF.Logistic regression analysis was used to assess the predictive value of rectal ACF for progressive adenomas and CRC, and to identify the independent risk factors of ACF.Results Large number of ACF, i.e.more than 5, was a significant risk factor for CRC and progressive adenomas.Age and smoking were both risk factors of ACF, while aspirin was a protective factor.Conclusion ACF of more than 5 is predictive of CRC and progressive adenomas.For prevention of CRC, great importance must be attached to risk factors of ACF.