肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
z1期
5-7
,共3页
石秀娥%徐建旺%马佳玲%刘海%贾明峰%刘春霞%席亚明
石秀娥%徐建旺%馬佳玲%劉海%賈明峰%劉春霞%席亞明
석수아%서건왕%마가령%류해%가명봉%류춘하%석아명
细胞色素 P450 CYP2E1%基因多态性%易感性%急性白血病
細胞色素 P450 CYP2E1%基因多態性%易感性%急性白血病
세포색소 P450 CYP2E1%기인다태성%역감성%급성백혈병
Cytochrome P450 CYP2E1%Genetic polymorphism%Susceptibility%Acute leukemia
目的 研究甘肃省人群CYP2E1基因多态性和急性白血病易感性的关系.方法 用1∶1配对病例-对照方法,LDR-PCR方法,对甘肃省人群中100例急性白血病患者和100例对照进行CYP2E1基因突变分析.结果 急性白血病组CYP2E1基因C2等位基因频率(13.5%)和CIC2+C2C2基因型频率(22%)均高于对照组(10.5%和19%),但其差异均无统计学意义.进一步分层分析,急性髓系白血病(AML)组C1C2/C2C2基因型频率(27%)高于对照组(19%),其差异无统计学意义.急性淋巴细胞白血病(ALL)组CYP2E1基因C2等位基因频率和C1C2/C2C2基因型频率均与对照组差异无统计学意义(x2=0.446,P=0.504>0.05).结论 甘肃省研究人群CYP2E1基因多态性与急性白血病(AML和ALL)遗传易感性无关.
目的 研究甘肅省人群CYP2E1基因多態性和急性白血病易感性的關繫.方法 用1∶1配對病例-對照方法,LDR-PCR方法,對甘肅省人群中100例急性白血病患者和100例對照進行CYP2E1基因突變分析.結果 急性白血病組CYP2E1基因C2等位基因頻率(13.5%)和CIC2+C2C2基因型頻率(22%)均高于對照組(10.5%和19%),但其差異均無統計學意義.進一步分層分析,急性髓繫白血病(AML)組C1C2/C2C2基因型頻率(27%)高于對照組(19%),其差異無統計學意義.急性淋巴細胞白血病(ALL)組CYP2E1基因C2等位基因頻率和C1C2/C2C2基因型頻率均與對照組差異無統計學意義(x2=0.446,P=0.504>0.05).結論 甘肅省研究人群CYP2E1基因多態性與急性白血病(AML和ALL)遺傳易感性無關.
목적 연구감숙성인군CYP2E1기인다태성화급성백혈병역감성적관계.방법 용1∶1배대병례-대조방법,LDR-PCR방법,대감숙성인군중100례급성백혈병환자화100례대조진행CYP2E1기인돌변분석.결과 급성백혈병조CYP2E1기인C2등위기인빈솔(13.5%)화CIC2+C2C2기인형빈솔(22%)균고우대조조(10.5%화19%),단기차이균무통계학의의.진일보분층분석,급성수계백혈병(AML)조C1C2/C2C2기인형빈솔(27%)고우대조조(19%),기차이무통계학의의.급성림파세포백혈병(ALL)조CYP2E1기인C2등위기인빈솔화C1C2/C2C2기인형빈솔균여대조조차이무통계학의의(x2=0.446,P=0.504>0.05).결론 감숙성연구인군CYP2E1기인다태성여급성백혈병(AML화ALL)유전역감성무관.
Objective To study the relationship between genetic polymorphisms of CYP2E1 and the susceptibility of the acute leukemia in Gansu population. Methods The C609T polymorphism of CYP2E1 gene was detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) and 1∶1 matched casecontrol method in 100 healthy persons (control group) and 100 patients with acute leukemia (AL group).Results The C2 allele genotype and C1C2/C2C2 genotype of CYP2E1 gene occurred more frequently in AL group (13.5 % and 22 %, respectively) than those in control group (10.5 % and 19 %, respectively), however,both differences showed no statistical significant. Further stratified analysis, the C1C2/C2C2 genotype of CYP2E1 gene occurred more frequently in AML group (27%) than that in control group (19 %), but difference had no statistical significant, too. The occurrence frequency of the C2 allele genotype and C1C2/C2C2 genotype of CYP2E1 gene showed no significant difference in ALL group and control group (x2=0.446, P =0.504>0.05). Conclusion Genetic polymorphisms of CYP2E1 don't correlated to susceptibility of acute leukemia(AML and ALL) in Gansu population.
