CAJ | 학술논문

目的探讨胰岛素原（PI）、真胰岛素（TI）是否与冠心病危险因素相关。方法采用BA-ELISA法测定119例入选者口服葡萄糖耐量试验（OGTT）各时相的PI、TI水平，并与冠心病危险因素及其数目作相关分析。结果空腹及糖负荷2h PI、TI与冠心病危险因素数目（r=0.19～0.33）、体重指数(BMI)（r=0.23～0.41）及WHR（r=0.32～0.51）呈正相关，而与HDL-C（r=-0.22～-0.30）负相关；空腹PI及2h 糖负荷PI、TI与高血压（r=0.18～0.20）、葡萄糖耐量减低(IGT)（r=0.13～0.34）、TG（r=0.32～0.33）和尿酸（r=0.27～0.36）呈正相关，空腹及2h PI与apoB（r=0.26）呈正相关，2h PI与TC(r=0.21)及家族史(r=0.21)呈正相关；经校正年龄、性别、BMI、WHR(腰臀比值)、空腹及2h血糖后，TI与血脂的关系消失，PI与血脂的关系减弱：空腹PI与TG（r=0.32）、apoB(r=0.19）及尿酸（r=0.22）呈正相关， 2h PI与apoB(r=0.27)及尿酸（r=0.20）正相关，与HDL-C（r=-0.21）呈负相关；多元逐步回归分析法亦显示PI与血脂的关系比TI更密切。结论 PI、TI与冠心病危险因素有明显关系，而且PI比TI与冠心病危险因素的关系更密切。
목적탐토이도소원（PI）、진이도소（TI）시부여관심병위험인소상관。방법채용BA-ELISA법측정119례입선자구복포도당내량시험（OGTT）각시상적PI、TI수평，병여관심병위험인소급기수목작상관분석。결과공복급당부하2h PI、TI여관심병위험인소수목（r=0.19～0.33）、체중지수(BMI)（r=0.23～0.41）급WHR（r=0.32～0.51）정정상관，이여HDL-C（r=-0.22～-0.30）부상관；공복PI급2h 당부하PI、TI여고혈압（r=0.18～0.20）、포도당내량감저(IGT)（r=0.13～0.34）、TG（r=0.32～0.33）화뇨산（r=0.27～0.36）정정상관，공복급2h PI여apoB（r=0.26）정정상관，2h PI여TC(r=0.21)급가족사(r=0.21)정정상관；경교정년령、성별、BMI、WHR(요둔비치)、공복급2h혈당후，TI여혈지적관계소실，PI여혈지적관계감약：공복PI여TG（r=0.32）、apoB(r=0.19）급뇨산（r=0.22）정정상관， 2h PI여apoB(r=0.27)급뇨산（r=0.20）정상관，여HDL-C（r=-0.21）정부상관；다원축보회귀분석법역현시PI여혈지적관계비TI경밀절。결론 PI、TI여관심병위험인소유명현관계，이차PI비TI여관심병위험인소적관계경밀절。
Objective　To explore whether proinsulin (PI) and true insulin (TI) are related to cardiovascular risk factors. Methods　PI and TI levels of 119 subjects during 2 h 75 g OGTT after an overnight 14 h fast were detected by BA-ELISA in which proinsulin crossreactivity is less than 0.1%. The relationship between PI, TI levels and traditional cardiovascular risk factors was assessed by spearman correlation, partial corrclation and multiple regression analysis. Results　Fasting and 2h PI, TI were positively related to the number of traditional cardiovascular risk factors (r=0.19－0.33), BMI (r=0.23－0.41) and WHR (r=0.32－0.51), negatively related to HDL-C　(r=-0.22－ -0.30). Fasting PI and 2h PI, TI were positively associated with IGT (r=0.13－0.34), hypertension　(r=0.18－0.20), UA　(r=0.27－0.36) and TG (r=0.32－0.33), fasting and 2h PI were positively related to apolipoprotein B　(r=0.26), 2h PI was also positively related to TC　(r=0.22); but after adjusting for age, sex, BMI, WHR, fasting and 2h blood glucose, the relationship between TI and blood lipids disappeared, the relationship between PI and blood lipids weakened or disappeared. In multiple regression analyses, PI level was more strongly associated with triglycerides, total cholesterol and apolipoprotein B than TI level. Conclusion　PI and TI, whether fasting or post-glucose loading, are closely related to cardiovascular risk factors.