CAJ | 학술논문

目的探讨痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮临床疗效及安全性,寻求有效的治疗方案.方法选择104例女性青春期后痤疮患者,随机开放分为验证组及对照组,验证组每天中午皮损处外用痤疮涂膜剂,同时每晚睡前患处涂沫0.1%阿达帕林凝胶一次;对照组仅单纯每晚外用阿达帕林凝胶患处一次.治疗8周,评定疗效,观察随访.结果验证组治愈率36.5%,有效率达96.2%;对照组治愈率15.4%,有效率82.7%.两组治愈率、有效率比较经x2检验P＜0.05,均有统计学差异.结论痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮疗效显著,且不良反应轻微,方法安全简便,患者易接受,值得临床推广应用.
목적 탐토좌창도막제연합아체파림치료녀성청춘기후좌창림상료효급안전성,심구유효적치료방안.방법 선택104례녀성청춘기후좌창환자,수궤개방분위험증조급대조조,험증조매천중오피손처외용좌창도막제,동시매만수전환처도말0.1%아체파림응효일차;대조조부단순매만외용아체파림응효환처일차.치료8주,평정료효,관찰수방.결과 험증조치유솔36.5%,유효솔체96.2%;대조조치유솔15.4%,유효솔82.7%.량조치유솔、유효솔비교경x2검험P＜0.05,균유통계학차이.결론 좌창도막제연합아체파림치료녀성청춘기후좌창료효현저,차불량반응경미,방법안전간편,환자역접수,치득림상추엄응용.
Objective To investigate clinical efficacy and safety of the combined adapalene and acne pellicles to treat women acne after puberty, and find effective treatment. Methods 104 cases of female patients with acne after puberty ,were randomly divided into validation group and control group, the validation group were smeared acne pellicles on acne lesion at noon and 0. 1 % adapalene on night before bed once; while the control group only were smeared adapalene on acne lesion once at night. It was 8 weeks to assess the efficacy and followup observation. Results The validation group cure rate was 36. 5%, the effective rate was 96. 2%, while the control group cure rate was 15.4% and 82. 7% respectively. The cure rate and efficient of two groups were significant differences by chi-square test P ＜ 0. 05. Conclusion The combined adapalene and acne pellicles treatment of female puberty acne had significant effect, mild side effects and meyhod dimple, and easy to accept by the patient. It is worth clinical application.