CAJ | 학술논문

目的观察甲状腺功能减退症（甲减）患者激素替代治疗前后血脂和心肌酶谱的变化及意义。方法检测72例甲减患者（观察组）治疗前后和60例健康对照组血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、天门冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(HBDH)和肌酸肌酶同工酶(CKMB)水平。结果观察组治疗前TC、TG和LDL-C水平均明显高于对照组（均P＜0.05），而治疗后水平明显下降（均P＜0.05），略高于对照组，但差异无统计学意义（均P＞0.05）。观察组治疗前AST、LDH、HBDH和CKMB水平明显高于对照组（均P＜0.05），而治疗后AST、LDH、HBDH和CKMB水平明显下降（均P＜0.05），治疗后AST、LDH、HBDH和CKMB水平与对照组比较，差异无统计学意义（均P＞0.05）。结论甲减患者经激素替代治疗后血脂和心肌酶谱基本恢复正常，对于防治心血管疾病具有重要意义。
목적 관찰갑상선공능감퇴증（갑감）환자격소체대치료전후혈지화심기매보적변화급의의。방법 검측72례갑감환자（관찰조）치료전후화60례건강대조조혈청중총담고순(TC)、감유삼지(TG)、저밀도지단백담고순(LDL-C)、천문동안산전안매(AST)、유산탈경매(LDH)、α-간정산탈경매(HBDH)화기산기매동공매(CKMB)수평。결과 관찰조치료전TC、TG화LDL-C수평균명현고우대조조（균P＜0.05），이치료후수평명현하강（균P＜0.05），략고우대조조，단차이무통계학의의（균P＞0.05）。관찰조치료전AST、LDH、HBDH화CKMB수평명현고우대조조（균P＜0.05），이치료후AST、LDH、HBDH화CKMB수평명현하강（균P＜0.05），치료후AST、LDH、HBDH화CKMB수평여대조조비교，차이무통계학의의（균P＞0.05）。결론 갑감환자경격소체대치료후혈지화심기매보기본회복정상，대우방치심혈관질병구유중요의의。
Objective To observe the changes and significance of blood fat and myocardial enzymes in patients with hypothyroid myopathy before and after substitutional treatment.Methods The levels of TC, TG, LDL-C,AST, LDH, HBDH and CKMB were detected in 72 cases with hypothyroid myopathy patients before and after substitutional treatment and 60 healthy controls. Results The levels of TC,TG and LDL-C in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group ( all P ＜ 0. 05 ), and then significantly low after treatment,which had no significant difference with control group( all P ＞0. 05). The levels of AST,LDH,HBDH and CKMB in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group( all P ＜ 0. 05 ) ,and then significantly low after treatment,which had no significant difference with control group( all P ＞0. 05). Conclusion The levels of blood fat and myocardial enzymes were significantly increased in hypothyroid myopathy patients, and recovery to normal after substitutional treatment.