中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
21期
24-27
,共4页
肉瘤,粒细胞%髓系细胞%免疫组织化学
肉瘤,粒細胞%髓繫細胞%免疫組織化學
육류,립세포%수계세포%면역조직화학
Sarcoma,granulocytic%Myeloid cells%Immunohistochemistry
目的 探讨卵巢孤立性粒细胞肉瘤的临床病理特点、诊断及鉴别诊断要点.方法 结合文献对1例双侧卵巢孤立性粒细胞肉瘤的临床表现、病理特征、免疫表型及治疗预后进行分析.结果 卵巢孤立性粒细胞肉瘤是一种罕见肿瘤,迄今查到14例报道.本例表现为右卵巢被灰绿色肿物取代,大小10.0cm×8.5 cm×6.0 cm;左卵巢大小4.8 cm×3.0 cm×2.2 cm,部分被肿瘤取代.肿瘤细胞呈弥漫性分布或列兵样排列.细胞分化程度不等,以原始未成熟细胞为主,可找到幼稚嗜酸粒细胞.免疫组化:肿瘤细胞髓过氧化物酶(MP0)(+)、CD117(+)、CD43(+)、CD79α(-)、CD3(-).结论 仅凭常规形态学观察,卵巢孤立性粒细胞肉瘤易误诊为淋巴瘤、颗粒细胞瘤等.细胞分化程度不等,列兵样排列、幼稚嗜酸粒细胞的出现是重要的诊断线索.免疫组化是获得正确诊断的主要依据.即使病变位于局部仍需行抗白血病化疗.
目的 探討卵巢孤立性粒細胞肉瘤的臨床病理特點、診斷及鑒彆診斷要點.方法 結閤文獻對1例雙側卵巢孤立性粒細胞肉瘤的臨床錶現、病理特徵、免疫錶型及治療預後進行分析.結果 卵巢孤立性粒細胞肉瘤是一種罕見腫瘤,迄今查到14例報道.本例錶現為右卵巢被灰綠色腫物取代,大小10.0cm×8.5 cm×6.0 cm;左卵巢大小4.8 cm×3.0 cm×2.2 cm,部分被腫瘤取代.腫瘤細胞呈瀰漫性分佈或列兵樣排列.細胞分化程度不等,以原始未成熟細胞為主,可找到幼稚嗜痠粒細胞.免疫組化:腫瘤細胞髓過氧化物酶(MP0)(+)、CD117(+)、CD43(+)、CD79α(-)、CD3(-).結論 僅憑常規形態學觀察,卵巢孤立性粒細胞肉瘤易誤診為淋巴瘤、顆粒細胞瘤等.細胞分化程度不等,列兵樣排列、幼稚嗜痠粒細胞的齣現是重要的診斷線索.免疫組化是穫得正確診斷的主要依據.即使病變位于跼部仍需行抗白血病化療.
목적 탐토란소고립성립세포육류적림상병리특점、진단급감별진단요점.방법 결합문헌대1례쌍측란소고립성립세포육류적림상표현、병리특정、면역표형급치료예후진행분석.결과 란소고립성립세포육류시일충한견종류,흘금사도14례보도.본례표현위우란소피회록색종물취대,대소10.0cm×8.5 cm×6.0 cm;좌란소대소4.8 cm×3.0 cm×2.2 cm,부분피종류취대.종류세포정미만성분포혹렬병양배렬.세포분화정도불등,이원시미성숙세포위주,가조도유치기산립세포.면역조화:종류세포수과양화물매(MP0)(+)、CD117(+)、CD43(+)、CD79α(-)、CD3(-).결론 부빙상규형태학관찰,란소고립성립세포육류역오진위림파류、과립세포류등.세포분화정도불등,렬병양배렬、유치기산립세포적출현시중요적진단선색.면역조화시획득정학진단적주요의거.즉사병변위우국부잉수행항백혈병화료.
Objective To investigate the clinical and pathological features,diagnosis and differential diagnosis of isolated granulocytic sarcoma of the ovary. Methods The clinical manifestations,pathological features,immunohistochemistry,treatment and prognosis were analyzed in 1 case of isolated granulocytic sarcoma of the bilateral ovary with the review of literatures. Results Granulocytic sarcoma of the ovary was rare. Only 14 cases had been reported so far. This case presented a greenish masse arising from the right ovary measuring 10.0 cm × 8.5 cm × 6.0 cm and 4.8 cm × 3.0 cm × 2.2 cm mass in the left ovary. The neoplastic cells grew in a diffuse pattern or India file, composed of myeloid cells at various stages of maturation, being predominantly primitive myelocytes with a few immature eosinophils. Immunohistochemistry,tumor cells were strongly positive for MPO,CD117,CD43,but negative for CD79α,CD3 Conclusions In routine morpholog,granulocytic sarcoma may be misinterpreted as lymphoma,granular cell tumor,et al. Neoplastic cells at various stages of maturation,India file pattern and immature eosinophils are important diagnostic clues. Immunohistochemical stains are essential in order to obtain correct diagnosis. Despite the localized nature of tumor, intensive antileukemia chemotherapy is necessary.
