CAJ | 학술논문

目的探讨胃间质瘤(GST)的临床表现、病理特点及诊断、治疗.方法回顾性分析18例GST患者的临床和病理资料.分析GST的临床特点、诊断治疗.结果临床表现主要为上腹部不适,隐痛或腹胀、消化道出血和腹部包块.术前无一例确诊,均接受手术治疗.17例完整切除,1例局部切除.常规病理检查见梭形细胞.免疫组织化学检测CD117阳性16例,CD34阳性11例.结论GST消化道症状无特异性,术前确诊率低,免疫组织化学检查可明确诊断,肿瘤大小是判断良恶性GST的重要指标.目前手术切除仍为主要治疗方法,适当的甲磺酸伊马替尼治疗可以改善GST患者的预后.
목적탐토위간질류(GST)적림상표현、병리특점급진단、치료.방법회고성분석18례GST환자적림상화병리자료.분석GST적림상특점、진단치료.결과림상표현주요위상복부불괄,은통혹복창、소화도출혈화복부포괴.술전무일례학진,균접수수술치료.17례완정절제,1례국부절제.상규병리검사견사형세포.면역조직화학검측CD117양성16례,CD34양성11례.결론GST소화도증상무특이성,술전학진솔저,면역조직화학검사가명학진단,종류대소시판단량악성GST적중요지표.목전수술절제잉위주요치료방법,괄당적갑광산이마체니치료가이개선GST환자적예후.
Objective To discuss the clinical characteristics of gastric stromal tumor (GST),as well as their diagnosis and treatment.Methods The clinical and pathological data of 18 patients with GST were retrospectively analyzed.Results The chief clinical manifestations included abdominal pain or discomfort,gastrointestinal bleeding and the abdominal mass.Only a rectum stromal tumor in 1 case diagnosed before operation.All the 18 patients were treated surgically,of all 17 cases were resected completely,1 case was rssected palliatively. The microscopic pathological morphology were exclusively fusiform cells,immunohistochemical analysis display positive reactivity for CD117 ( 16/18 ),CD34 ( 11/18 ),positive reactivity for CD117 and CD34 (15/18).Conclusion The confirmed diagnosis rate of preoperative-GIST is low and digestive tract symptoms have no specific.The diagnosis of GST mainly depends on pathologicl analysis.The size of the tumor is the important marker to the diagnosis of benign of malignant GST.At present,the operation is still the main method to treat GST.Appropriate treatment with Glivec can improve the prognoeis of patients with GST.