CAJ | 학술논문

目的探讨帕洛诺司琼联合小剂量的地塞米松在防治顺铂引起的恶心、呕吐中的疗效和安全性.方法采用随机信封方法将60例采用顺铂化疗的肿瘤患者分为对照组(29例)和联合组(31例).对照组用药为盐酸帕洛诺司琼注射液0.25 mg,第1、3天静脉注射；联合组在对照组基础上联合地塞米松5 mg/d,第1～3天静脉推注.对化疗后恶心呕吐疗效进行评价,并观察地塞米松所致的不良反应.结果化疗期间,对照组急性呕吐有效22例(75.9％),无效7例(24.1％),延迟性呕吐有效20例(69.0％),无效9例(31.0％).联合组急性呕吐有效24例(77.4％),无效7例(22.6％)；延迟性呕吐有效26例(83.9％),无效5例(16.1％).联合组对于延迟性呕吐疗效优于对照组(P＜0.05).地塞米松应用期间,发生血压和血糖升高2例,兴奋1例,失眠1例,皮疹1例,但均可控制.结论盐酸帕洛诺司琼注射液联合小剂量的地塞米松能够预防化疗引起的延迟性恶心、呕吐,疗效和安全性较好.
목적 탐토파락낙사경연합소제량적지새미송재방치순박인기적악심、구토중적료효화안전성.방법 채용수궤신봉방법장60례채용순박화료적종류환자분위대조조(29례)화연합조(31례).대조조용약위염산파락낙사경주사액0.25 mg,제1、3천정맥주사；연합조재대조조기출상연합지새미송5 mg/d,제1～3천정맥추주.대화료후악심구토료효진행평개,병관찰지새미송소치적불량반응.결과 화료기간,대조조급성구토유효22례(75.9％),무효7례(24.1％),연지성구토유효20례(69.0％),무효9례(31.0％).연합조급성구토유효24례(77.4％),무효7례(22.6％)；연지성구토유효26례(83.9％),무효5례(16.1％).연합조대우연지성구토료효우우대조조(P＜0.05).지새미송응용기간,발생혈압화혈당승고2례,흥강1례,실면1례,피진1례,단균가공제.결론 염산파락낙사경주사액연합소제량적지새미송능구예방화료인기적연지성악심、구토,료효화안전성교호.
Objective To investigate the efficacy and safety of palonosetron hydrochloride combined with decreased dexamethasone in prevention of nausea and vomit induced by cisplatin.Methods All cases were randomly divided into two groups,29 cases in control group (treated with palonosetron 0.25mg) and 31 cases in combined group (treated with palonosetron 0.25 mg and dexamethasone 5 mg).Results Effective rate of acute vomit in combined group was higher than that in control group [77.4％ (24 cases) vs 75.9％ (22 cases),P＞0.05] ; effective rate of delayed emesis in combined group was also higher that in control group,the difference was statistically significant [83.9％ (26 cases) vs 69.0％ (20 cases),P ＜0.05].Increased incidence of blood pressure and serum glucose,insomnia,agitation,skin rash were observed when dexamethasone was used.Conclusion Palonosetron hydrochloride combined with decreased dexamethasone is effective and safe for prevention of delayed nausea and vomit induced by cisplatin.