CAJ | 학술논문

The quantitative relationship between HBV pro-s gene products(pHSA reoeptor)andHBeAg,DNA-P,viral partiole,perinatal transmission of HBsAg from oarrier mothers totheir newborn babies was studied.Among 59 chronio hepatitis B patients high titers ofpHSA receptor (≥1:1,000)were demonstrated in sera of 25 out of 29 with HBeAg positiveoases.In contrast.only 8 of 30 with HBeAg negative oases were pHSA receptor positivewithlower titers(≥1:100 or less).The DNA-P aotivity and pHSA receptor titer werehighly correlated in'chronio hepatitis B,the DNA-p aotivity in pHSA receptor negativepatients was 22.8±98.6cpm,while in high pHSA titer group(≥1:1,000)WaS 210±246.0cpm(P<0.01).Among 43 HBsAg positive pregnant women the pHSA receptor titers were1:1,000 in 15 oases,13 of their babies beoame HBsAg positive after 12 months,and pHSAreoeptor titers were≤1:J00 in 28 oases,only one of their babies beeame HBsAg positive after12 months.The electron mioroscopio examinations found that Dane particle had the moresibes of pHSA receptor than the 22-nm round HPsAg particle had.These results showedthat qualitative determination of pre-s gene products(pHSA reoeptor)may be a usefulmarker indicating the aotive replication of virus.