中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
2期
55-56
,共2页
缺铁性贫血%质子泵抑制剂%铁剂
缺鐵性貧血%質子泵抑製劑%鐵劑
결철성빈혈%질자빙억제제%철제
Iron deficiency anemia%Proton pump inhibitor%Ferralia
目的 治疗合并有消化性溃疡(PU)的缺铁性贫血(IDA)时,观察质子泵抑制剂对铁剂吸收的影响.方法 二种疾病需同时进行治疗的患者共116例,随机分为两组.A组服用H2受体拮抗剂+铁剂,B组服用质子泵抑制剂+铁剂,药物的服用剂量为常规剂量,治疗前检测有关生化指标,治疗过程中每周二次复查血常规和网织红细胞(RC),观察血红蛋白(Hb)的动态变化,共8周.结果 2周末,两组患者的Hb回升已经开始出现统计学差异(P＜0.05);8周末,A组患者Hb全部恢复正常,B组患者Hb部分恢复正常(91.9%)(P＜0.01),而且,从治疗开始到Hb恢复正常,服用质子泵抑制剂的患者所需时间比服用H2受体拮抗剂者明显延长(P＜0.01).结论 质子泵抑制剂可以阻碍铁剂的吸收,临床上应避免同时口服,必要时铁剂可考虑胃肠外给予.
目的 治療閤併有消化性潰瘍(PU)的缺鐵性貧血(IDA)時,觀察質子泵抑製劑對鐵劑吸收的影響.方法 二種疾病需同時進行治療的患者共116例,隨機分為兩組.A組服用H2受體拮抗劑+鐵劑,B組服用質子泵抑製劑+鐵劑,藥物的服用劑量為常規劑量,治療前檢測有關生化指標,治療過程中每週二次複查血常規和網織紅細胞(RC),觀察血紅蛋白(Hb)的動態變化,共8週.結果 2週末,兩組患者的Hb迴升已經開始齣現統計學差異(P＜0.05);8週末,A組患者Hb全部恢複正常,B組患者Hb部分恢複正常(91.9%)(P＜0.01),而且,從治療開始到Hb恢複正常,服用質子泵抑製劑的患者所需時間比服用H2受體拮抗劑者明顯延長(P＜0.01).結論 質子泵抑製劑可以阻礙鐵劑的吸收,臨床上應避免同時口服,必要時鐵劑可攷慮胃腸外給予.
목적 치료합병유소화성궤양(PU)적결철성빈혈(IDA)시,관찰질자빙억제제대철제흡수적영향.방법 이충질병수동시진행치료적환자공116례,수궤분위량조.A조복용H2수체길항제+철제,B조복용질자빙억제제+철제,약물적복용제량위상규제량,치료전검측유관생화지표,치료과정중매주이차복사혈상규화망직홍세포(RC),관찰혈홍단백(Hb)적동태변화,공8주.결과 2주말,량조환자적Hb회승이경개시출현통계학차이(P＜0.05);8주말,A조환자Hb전부회복정상,B조환자Hb부분회복정상(91.9%)(P＜0.01),이차,종치료개시도Hb회복정상,복용질자빙억제제적환자소수시간비복용H2수체길항제자명현연장(P＜0.01).결론 질자빙억제제가이조애철제적흡수,림상상응피면동시구복,필요시철제가고필위장외급여.
Objective To observe the influence of proton pump inhibitor on the absorption of ferralia,in the treatment of iron deficiency anemia(IDA) complicated with peptic ulcer( PU ). Methods There were 116patients required the therapies of both diseases in the same time, randomly divided into two groups. Group A took H2 receptor antagonist along with ferralia, group B took proton pump inhibitor along with ferralia, both were in normal dosage,related biochemical parameters were examined before the treatment, blood routine and reticulocyte ( RC ) were reexamined twice a week during the therapy in order to observe the dynamic change of the hemoglobin(Hb). The total process lasted for 8 weeks. Results At the end of 2nd week, differences occurred between the two groups in the increasing of Hb( P ＜ 0.05 ), at the end of 8th week, Hb of all the patients in group A returned to normal, while group B partially returned to normal(91.9% ) (P ＜ 0.01 ). Furthermore, it took patients who took proton pump inhibitor far more time to achieve the normalization of Hb than those patients who took H2 receptor antagonist (P ＜ 0.01 ). Conclusion Proton pump inhibitor can hinder the absorption of ferralia, thus both medicines orally taken at the same time should be avoided, or parenteral feeding of ferralia should be considered if necessary.
