中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
5期
71-72
,共2页
血尿酸%冠心病%血小板最大聚集率
血尿痠%冠心病%血小闆最大聚集率
혈뇨산%관심병%혈소판최대취집솔
Serum uric acid%Coronary heart disease%Maximum platelet aggregation rate
目的 探讨血尿酸与冠心病的相关性及尿酸水平的变化对血小板聚集功能的影响.方法 将120例疑诊为冠心病的患者根据冠状动脉造影结果分为冠心病组(85例)和正常对照组(35例),比较两组间尿酸水平及血小板最大聚集率(MPAR)的差异.同时对冠心病伴高尿酸血症患者进行别嘌醇干预治疗4周,对比分析用药前后尿酸水平及血小板最大聚集率的变化.结果 冠心病组血尿酸、MPAR水平显著高于对照组(P＜0.05),单因素相关分析发现冠心病组血尿酸水平与血小板聚集率呈正相关关系(r=0.598,P＜0.05),冠心病伴高尿酸血症患者服药后血尿酸、MPAR水平显著低于服药前(P＜0.05),差别均有统计学意义.结论 尿酸可激活血小板,促进血小板的粘附、聚集和释放,是冠心病形成及发展过程中的重要危险因素
目的 探討血尿痠與冠心病的相關性及尿痠水平的變化對血小闆聚集功能的影響.方法 將120例疑診為冠心病的患者根據冠狀動脈造影結果分為冠心病組(85例)和正常對照組(35例),比較兩組間尿痠水平及血小闆最大聚集率(MPAR)的差異.同時對冠心病伴高尿痠血癥患者進行彆嘌醇榦預治療4週,對比分析用藥前後尿痠水平及血小闆最大聚集率的變化.結果 冠心病組血尿痠、MPAR水平顯著高于對照組(P＜0.05),單因素相關分析髮現冠心病組血尿痠水平與血小闆聚集率呈正相關關繫(r=0.598,P＜0.05),冠心病伴高尿痠血癥患者服藥後血尿痠、MPAR水平顯著低于服藥前(P＜0.05),差彆均有統計學意義.結論 尿痠可激活血小闆,促進血小闆的粘附、聚集和釋放,是冠心病形成及髮展過程中的重要危險因素
목적 탐토혈뇨산여관심병적상관성급뇨산수평적변화대혈소판취집공능적영향.방법 장120례의진위관심병적환자근거관상동맥조영결과분위관심병조(85례)화정상대조조(35례),비교량조간뇨산수평급혈소판최대취집솔(MPAR)적차이.동시대관심병반고뇨산혈증환자진행별표순간예치료4주,대비분석용약전후뇨산수평급혈소판최대취집솔적변화.결과 관심병조혈뇨산、MPAR수평현저고우대조조(P＜0.05),단인소상관분석발현관심병조혈뇨산수평여혈소판취집솔정정상관관계(r=0.598,P＜0.05),관심병반고뇨산혈증환자복약후혈뇨산、MPAR수평현저저우복약전(P＜0.05),차별균유통계학의의.결론 뇨산가격활혈소판,촉진혈소판적점부、취집화석방,시관심병형성급발전과정중적중요위험인소
Objective To discuss the correlation with coronary heart diaease and effects on platelet aggregation function of serum uric acid(SUA).Methods 120 patients diagnosed as suspected coronary heart disease were divided into two groups coronary heart diaease group(85cases) and normal control group(35 cases)according to coronary angiography.Comparing the differences of SUA level and Maximum platelet aggregation rate (MPAR).Besides,the coronary heart disease with high SUA patients were interfered with allopurinol for 4 weeks.Analysing the changes of SUA level and MPAR before and after treatment.Results The SUA level and MPAR of the former group were significantly higher(P ＜ 0.05)than the latter group.Single-factor correlation analysis showed that uric acid levels and platelet aggregation rate were positively correlated (r = 0.598,P ＜0.05) in coronary heart disease group.The SUA level and MPAR of coronary heart disease patients with hyperuricemia taking medicie were significantly lower than before treatment (P ＜ 0.05).The differences were statistically significant.Conclusion SUA can activate platelets and promote platelet adhesion,aggregation and release and was an important risk factor in the formation and development of coronary heart disease.
