国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
21期
28-31
,共4页
磷酸川芎嗪注射液%血管刺激%体外溶血%豚鼠全身主动过敏性试验%大鼠被动皮肤过敏试验
燐痠川芎嗪註射液%血管刺激%體外溶血%豚鼠全身主動過敏性試驗%大鼠被動皮膚過敏試驗
린산천궁진주사액%혈관자격%체외용혈%돈서전신주동과민성시험%대서피동피부과민시험
Lingustration Phosphate Injection%Vascular stimulation%Haemocytolysis in vitro%ASA%PCA
目的 观察磷酸川芎嗪注射液是否具有血管刺激性、溶血性和过敏作用,评价其注射用药的安全性.方法 通过兔耳缘静脉刺激性试验、体外溶血性试验、豚鼠全身主动过敏性试验(ASA)和大鼠被动皮肤过敏试验(PCA),试验观察磷酸川芎嗪注射液的安全性.结果 磷酸川芎嗪注射液埘家兔耳静脉注射无明显刺激性;对家兔血细胞无溶血和凝集反应;豚鼠全身主动过敏性试验亦无动物出现过敏症状;在大鼠被动皮肤过敏试验中仅低剂量组有20%动物出现过敏反应症状.结论 在本次实验条件下,除磷酸川芎嗪注射液低剂量组有轻微过敏反应症状外,其注射使用是安全的.
目的 觀察燐痠川芎嗪註射液是否具有血管刺激性、溶血性和過敏作用,評價其註射用藥的安全性.方法 通過兔耳緣靜脈刺激性試驗、體外溶血性試驗、豚鼠全身主動過敏性試驗(ASA)和大鼠被動皮膚過敏試驗(PCA),試驗觀察燐痠川芎嗪註射液的安全性.結果 燐痠川芎嗪註射液塒傢兔耳靜脈註射無明顯刺激性;對傢兔血細胞無溶血和凝集反應;豚鼠全身主動過敏性試驗亦無動物齣現過敏癥狀;在大鼠被動皮膚過敏試驗中僅低劑量組有20%動物齣現過敏反應癥狀.結論 在本次實驗條件下,除燐痠川芎嗪註射液低劑量組有輕微過敏反應癥狀外,其註射使用是安全的.
목적 관찰린산천궁진주사액시부구유혈관자격성、용혈성화과민작용,평개기주사용약적안전성.방법 통과토이연정맥자격성시험、체외용혈성시험、돈서전신주동과민성시험(ASA)화대서피동피부과민시험(PCA),시험관찰린산천궁진주사액적안전성.결과 린산천궁진주사액시가토이정맥주사무명현자격성;대가토혈세포무용혈화응집반응;돈서전신주동과민성시험역무동물출현과민증상;재대서피동피부과민시험중부저제량조유20%동물출현과민반응증상.결론 재본차실험조건하,제린산천궁진주사액저제량조유경미과민반응증상외,기주사사용시안전적.
Objective To observe whether Lingustrazine Phosphate for injection has vascular stimulation,haemocytolysis and anaphylaxis.Methods The safety of Lingustrazine Phosphate for injection were observed through vascular stimulation test of ear vein in rabbit,hemolytic test using rabbit erythrocyte in vitro,active systemic anaphylaxis(ASA)in guinea pig and passive cutaneous anaphylaxis(PCA)in rats.Results The results showed that the Lingustrazine Phosphate Injection played no vascular irritative effects,and the haemocytolysis and agglutination reaction were both negatives.The results of active systemic anaphylaxis were negative and the passive cutaneous anaphylaxis were positive only 20% in rats.Conclusions The results showed that the Lingustrazine Phosphate Injection should be safe,excepted for the slightly allergic reactions displayed in low dose group under the experimental conditions.
