精细与专用化学品
精細與專用化學品
정세여전용화학품
FINE AND SPECIALTY CHEMICALS
2011年
9期
30-34
,共5页
尉宏伟%王瑛%李学敏%苗雨
尉宏偉%王瑛%李學敏%苗雨
위굉위%왕영%리학민%묘우
3,4-二羟基苯腈%香兰素%脱甲基化%3-甲氧基-4-羟基苯腈
3,4-二羥基苯腈%香蘭素%脫甲基化%3-甲氧基-4-羥基苯腈
3,4-이간기분정%향란소%탈갑기화%3-갑양기-4-간기분정
3%4-dihydroxybenzonitrile%vanillin%demethylation%4-hydroxy-3-methoxybenzonitrile
以3-甲氧基-4-羟基苯甲醛（香兰素）为原料,经与盐酸羟胺反应得到3甲氧基-4-羟基苯腈,再与碱金属卤化物经脱甲基化反应合成3,4-二羟基苯腈,产品含量99.8%,以香兰素计总收率75.2%。与其他合成方法比较,这条合成路线更适合于工业化。
以3-甲氧基-4-羥基苯甲醛（香蘭素）為原料,經與鹽痠羥胺反應得到3甲氧基-4-羥基苯腈,再與堿金屬滷化物經脫甲基化反應閤成3,4-二羥基苯腈,產品含量99.8%,以香蘭素計總收率75.2%。與其他閤成方法比較,這條閤成路線更適閤于工業化。
이3-갑양기-4-간기분갑철（향란소）위원료,경여염산간알반응득도3갑양기-4-간기분정,재여감금속서화물경탈갑기화반응합성3,4-이간기분정,산품함량99.8%,이향란소계총수솔75.2%。여기타합성방법비교,저조합성로선경괄합우공업화。
4-hydroxy-3-methoxybenzonitrile was prepared using vanillin as the raw material,reacted with hydroxylamine hydrochloride.Then 3,4-dihydroxybenzonitrile was synthesized form 4-hydroxy-3-methoxybenzonitrile by demethylation with metal halide.A overall yield of 75.2%and a content of 99.8%were obtained.This synthetic route is more suitable than others for industrial.
