CAJ | 학술논문

目的通过对类风湿关节炎（RA）患者及非RA患者血清中的类风湿因子（RF）与抗环瓜氨酸肽抗体（抗-CCP抗体）水平测定，探讨抗-CCP抗体在RA的诊断价值．方法用酶联免疫吸附方法对49例RA、6l例非RA患者测定血清抗CCP抗体及RF，并对检测结果进行比较．结果49例RA患者中抗-CCP抗体阳性23例，61例非RA患者抗-CCP抗体阳性2例．抗-CCP抗体的特异性比RF高，但敏感性比RF低．结论抗-CCP抗体对RA具有高度的特异性，抗-CCP抗体对RA患者的诊断具有非常重要的价值．
목적통과대류풍습관절염（RA）환자급비RA환자혈청중적류풍습인자（RF）여항배과안산태항체（항-CCP항체）수평측정，탐토항-CCP항체재RA적진단개치．방법용매련면역흡부방법대49례RA、6l례비RA환자측정혈청항CCP항체급RF，병대검측결과진행비교．결과49례RA환자중항-CCP항체양성23례，61례비RA환자항-CCP항체양성2례．항-CCP항체적특이성비RF고，단민감성비RF저．결론항-CCP항체대RA구유고도적특이성，항-CCP항체대RA환자적진단구유비상중요적개치．
Objective To evaluate the significance of anti-cyclic citrullinated peptide antibody （anti CCP） in diagnosis of rheumatoid arthritis （RA） by comparing rheumatoid factor （RF） with anti-cyclic citrullinated peptide antibody （anti CCP）. Methods ELISA was used to detect anti-CCP in 49 RA patients and 61 patients without RA, and the results were analyzed. Results Positive anti-CCP was found in 23 patients with RF and 2 patients without RA, the specificity of anti CCP was higher than that of RF, while its sensibility was lower than that of RF. Conclusion Anti CCP had high degree of specificity to RA, and anti CCP was very important in diagnosis of RA patients.