CAJ | 학술논문

正常人体内的胰岛素样生长因子(insulin-like growth factor, IGF)通过受体和结合蛋白的调节,在细胞的增殖、分化和凋亡中起重要作用.越来越多的研究发现,IGF家族参与包括肺癌在内的众多恶性肿瘤的发生和发展.近年来对肺癌细胞系、肺癌组织和肺癌患者循环血中IGF及其家族成员开展的大量基础和临床研究的结果显示,IGF家族可能在肺癌的转化和恶性进展中起重要作用,抑制其受体信号通路可能为肺癌的综合治疗提供新靶点.针对IGF受体的单克隆抗体研究目前已进入Ⅱ期临床试验阶段,并显示出潜在的临床应用前景.本文就IGF家族在肺癌领域的最新研究进展进行综述.
정상인체내적이도소양생장인자(insulin-like growth factor, IGF)통과수체화결합단백적조절,재세포적증식、분화화조망중기중요작용.월래월다적연구발현,IGF가족삼여포괄폐암재내적음다악성종류적발생화발전.근년래대폐암세포계、폐암조직화폐암환자순배혈중IGF급기가족성원개전적대량기출화림상연구적결과현시,IGF가족가능재폐암적전화화악성진전중기중요작용,억제기수체신호통로가능위폐암적종합치료제공신파점.침대IGF수체적단극륭항체연구목전이진입Ⅱ기림상시험계단,병현시출잠재적림상응용전경.본문취IGF가족재폐암영역적최신연구진전진행종술.
Insulin-like growth factors (IGF), regulated by their receptors and binding proteins, play a pivotal role in human cell proliferation, differentiation and apoptosis. Increasing evidence has revealed that IGF system is involved in the genesis and progress of various malignancies including lung cancer. Recent studies in regard to IGF axis expression in the lung cancer cell lines, pulmonary tissue samples and blood circulation of lung cancer patients have shown that the IGF axis may contribute to the transformation and progression of lung cancer. Several researches have shown that a number of drugs targeting the IGF receptor are being investigated in clinical trials and suggest a potential therapeutic efficacy. This article reviews the updates and progress in the research of IGF axis in lung cancer.