CAJ | 학술논문

本文完成了一种具有潜在转移活性的层粘连蛋白核心三糖β-D-Gal-(1→4)-β-D-GlcpNAc.(1→6)-α-D-Manp-OMe的合成.以2-碘代叠氮乳糖为供体采用"叠氮碘糖基化"反应一步完成了2-脱氧-2-氨皋乳糖结构及1,2.反式-氨基乳糖糖苷键的立体选择性构建.这种方法能简易、高效地合成含氨基乳糖的寡糖,较好地避免了直接使用活性较差的2-氨基糖衍生物构建氨基乳糖模块.
본문완성료일충구유잠재전이활성적층점련단백핵심삼당β-D-Gal-(1→4)-β-D-GlcpNAc.(1→6)-α-D-Manp-OMe적합성.이2-전대첩담유당위공체채용"첩담전당기화"반응일보완성료2-탈양-2-안고유당결구급1,2.반식-안기유당당감건적입체선택성구건.저충방법능간역、고효지합성함안기유당적과당,교호지피면료직접사용활성교차적2-안기당연생물구건안기유당모괴.
A core trisaccharide of laminin,β-D-Gal-(l→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-OMe,with potential anti-tumor metastatic activity was designed and prepared.2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction.Simultaneously,1,2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield.This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor.