CAJ | 학술논문

目的探讨不同剂量阿托伐他汀早期干预治疗对急性心肌梗死患者血脂及血清高敏C反应蛋白的影响.方法 60例AMI患者随机分为大剂量阿托伐他汀(40 mg/d)治疗组(30例)和常规剂量阿托伐他汀(20 mg/d)治疗组(30例),分别在入院24 h内及服药后3、7 d测定患者血脂、高敏C反应蛋白,比较两组患者血脂、高敏C反应蛋白的变化.结果治疗7 d后20 mg/d及40 mg/d阿托伐他汀治疗组总胆固醇、低密度脂蛋白水平较治疗前有降低(P＜0.05),而且40 mg/d阿托伐他汀治疗组高敏C反应蛋白水平显著降低,与20 mg/d阿托伐他汀治疗组比较有显著差异(P＜0.01),而治疗前后两组间总胆固醇、低密度脂蛋白比较无统计学意义(P＞0.05).结论早期大剂量阿托伐他汀应用更能降低急性心肌梗死患者的高敏C反应蛋白水平,且阿托伐他汀的抗炎治疗独立于降脂之外.
목적 탐토불동제량아탁벌타정조기간예치료대급성심기경사환자혈지급혈청고민C반응단백적영향.방법 60례AMI환자수궤분위대제량아탁벌타정(40 mg/d)치료조(30례)화상규제량아탁벌타정(20 mg/d)치료조(30례),분별재입원24 h내급복약후3、7 d측정환자혈지、고민C반응단백,비교량조환자혈지、고민C반응단백적변화.결과 치료7 d후20 mg/d급40 mg/d아탁벌타정치료조총담고순、저밀도지단백수평교치료전유강저(P＜0.05),이차40 mg/d아탁벌타정치료조고민C반응단백수평현저강저,여20 mg/d아탁벌타정치료조비교유현저차이(P＜0.01),이치료전후량조간총담고순、저밀도지단백비교무통계학의의(P＞0.05).결론 조기대제량아탁벌타정응용경능강저급성심기경사환자적고민C반응단백수평,차아탁벌타정적항염치료독립우강지지외.
Objective To investigate the effect of different doses of atorvastatinon on serum high sensitivity C-reactive protein and blood lipid levels in early phase of acute myocardial infarction. Methods A total of 60 patients with AMI were randomly assigned into the large dosage of atorvastatin(40 mg/d)group(n=30) and the routine dosage of atorvastatin(20 mg/d) (n = 30). Serum levels of blood lipid, hs-CRP were measured with biochemistry assay 24 hour after admission and 3 days and 7 days after therapy. The difference in blood lipid, hs-CRP was compared between the two groups. Results Among the two groups, the levels of TC and LDL-C decreased significandy after treatment(P ＜ 0. 05), in the large dosage of atorvastatin group, the levels of hs-CRP decreased significandy comparing with the routine dosage of atorvastatin group(P ＜ 0. 01) , but no visible statistic differences were found in TC, and LDL-C among the two groups. Conclusion Effect of early atorvastatin therapy of the large dosage on serum hs-CRP leves is better than the routine dosage in patients with acute myocardial infarction. The anti-inflammatory effect of atorvastatin is not related to lipid lowering.