中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
7期
954-955,后插2,封3
,共4页
膀胱肿瘤%增殖诱导配体%免疫组织化学
膀胱腫瘤%增殖誘導配體%免疫組織化學
방광종류%증식유도배체%면역조직화학
Bladder carcinoma%A proliferation-inducing ligand%Immunohistochemistry
目的 观察增殖诱导配体(APRIL)在人膀胱癌组织中的表达.方法 应用免疫组织化学SP法检测19例复发性膀胱癌、46例无复发性膀胱癌、8例正常膀胱组织中APRIL的表达,比较3组之间的差异及膀胱癌病理分级G1(n=21)、G2(n=21)、G3(n=23)之间的差异.结果 APRIL在复发性膀胱癌、无复发性膀胱癌、正常膀胱组织中阳性表达率分别为94.7%(18/19)、82.6%(38/46)、0(0/8),APRIL在膀胱癌不同病理分级G1级(n=21)、G2级(n=21)、G3级(n=23)中阳性表达率分别为76.2%(16/21)、85.7%(18/21)、95.7%(22/23).APRIL在正常膀胱组织、无复发性膀胱癌、复发性膀胱癌表达依次增强,且各组差异有统计学意义(P<0.05).APRIL的阳性细胞表达计分在膀胱癌不同病理分级中差异有统计学意义(P<0.05).结论 APRIL蛋白的表达可能与膀胱癌的发生、发展和复发有关.
目的 觀察增殖誘導配體(APRIL)在人膀胱癌組織中的錶達.方法 應用免疫組織化學SP法檢測19例複髮性膀胱癌、46例無複髮性膀胱癌、8例正常膀胱組織中APRIL的錶達,比較3組之間的差異及膀胱癌病理分級G1(n=21)、G2(n=21)、G3(n=23)之間的差異.結果 APRIL在複髮性膀胱癌、無複髮性膀胱癌、正常膀胱組織中暘性錶達率分彆為94.7%(18/19)、82.6%(38/46)、0(0/8),APRIL在膀胱癌不同病理分級G1級(n=21)、G2級(n=21)、G3級(n=23)中暘性錶達率分彆為76.2%(16/21)、85.7%(18/21)、95.7%(22/23).APRIL在正常膀胱組織、無複髮性膀胱癌、複髮性膀胱癌錶達依次增彊,且各組差異有統計學意義(P<0.05).APRIL的暘性細胞錶達計分在膀胱癌不同病理分級中差異有統計學意義(P<0.05).結論 APRIL蛋白的錶達可能與膀胱癌的髮生、髮展和複髮有關.
목적 관찰증식유도배체(APRIL)재인방광암조직중적표체.방법 응용면역조직화학SP법검측19례복발성방광암、46례무복발성방광암、8례정상방광조직중APRIL적표체,비교3조지간적차이급방광암병리분급G1(n=21)、G2(n=21)、G3(n=23)지간적차이.결과 APRIL재복발성방광암、무복발성방광암、정상방광조직중양성표체솔분별위94.7%(18/19)、82.6%(38/46)、0(0/8),APRIL재방광암불동병리분급G1급(n=21)、G2급(n=21)、G3급(n=23)중양성표체솔분별위76.2%(16/21)、85.7%(18/21)、95.7%(22/23).APRIL재정상방광조직、무복발성방광암、복발성방광암표체의차증강,차각조차이유통계학의의(P<0.05).APRIL적양성세포표체계분재방광암불동병리분급중차이유통계학의의(P<0.05).결론 APRIL단백적표체가능여방광암적발생、발전화복발유관.
Objective To investigate the expression profile of a proliferation-inducing ligand (APRIL) in bladder carcinoma. Methods The SP immunohistochermical method was used to detect the APRIL expression level in 19 cases of bladder carcinoma with recurrence, 46 cases of bladder carcinoma without recurrence, and 8 cases of normal bladder tissues. A comparison was made between recurrence group and non-recurrence group, and among the pathological grades. Results The immunohistochemistry revealed that the positive rate of APRIL in 19 cases of bladder carcinoma with recurrence was 94.7% (18/ 19) , 82. 6% (38/46) in 46 cases of bladder carcinoma without recurrence, and 0 (0/8) in 8 cases of normal bladder tissues, among the pathological grades, G1, G2, G3, respectively was 76. 2% (16/21), 85.7% (18/21), 95. 7% (22/23). The positive rate and the score of staining intensity of APRIL in normal bladder tissues, tissues of bladder carcinoma without recurrence, and tissues of bladder carcinoma with recurrence were gradually increased (P<0.05). The difference among the pathological grades had significant difference (P<0.05). Conclusion These findings suggest that the APRIL expression could be a valuable prognostic marker for tumor occurrence, development and recurrence in bladder carcinoma.
