新型药物载体聚乙醇-聚丙交酯载药颗粒的制备及表征
신형약물재체취을순-취병교지재약과립적제비급표정
Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)-poly(D,L-lactide)block copolymers as novel drug carriers
  • 万方数据
    化工学报 화공학보
    JOURNAL OF CHEMICAL INDUSY AND ENGINEERING (CHINA)
    2006年 2期 461-464 ,共4页

    姜维%王运东%张建铮%甘泉%张汉威%贝建中%赵秀文%费维扬

    강유%왕운동%장건쟁%감천%장한위%패건중%조수문%비유양



    drug carriers%poly(ethylene glycol)%poly(D,L-lactide)%block copolymer%micelles


    Methoxy poly(ethylene glycol)-poly(D,L-lactide) block copolymers (PEG-PLA) were prepared through ring-opening polymerization.The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration (CMC) by fluorescence spectroscopy was 0.0056 mg·ml-1. The physical state of the inner core region of micelles was characterized with 1HNMR. The size of indomethacin (IMC) loaded micelles measured by dynamic light scattering (DLS) showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition, the nanoparticles with relatively high drug loading content (DLC) were obtained.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문