医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2005年
10期
1433-1434
,共2页
HTLV-Ⅰ%脊髓疾病%痉挛%偏瘫%白细胞介素6/血液%白细胞介素6/脑脊髓液
HTLV-Ⅰ%脊髓疾病%痙攣%偏癱%白細胞介素6/血液%白細胞介素6/腦脊髓液
HTLV-Ⅰ%척수질병%경련%편탄%백세포개소6/혈액%백세포개소6/뇌척수액
[目的]探讨白细胞介素6(IL-6)在人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病/热带痉挛性瘫痪(HAM/TSP)发病中的作用.[方法]应用免疫放射方法检测8例HAM/TSP患者血清及脑脊液中IL-6水平.[结果]HAM/TSP 患者血清及脑脊液中IL-6含量分别为(194.76±30.01) pg/ml;(184.12±36.39) pg/ml,而其他神经系统疾病(OIND)组血清及脑脊液中IL-6含量分别为(132.61±21.76) pg/ml;(124. 95±15.39) pg/ml,正常对照组(NC) 组血清IL-6含量为(127.08±22.05) pg/mL.HAM/TSP患者血清及脑脊液IL-6水平均明显高于正常对照组(P<0.01);但HAM/TSP患者血清中IL-6含量与脑脊液中IL-6含量水平不呈线性相关.[结论]IL-6在HAM/TSP发病的免疫机制中可能起到重要作用.
[目的]探討白細胞介素6(IL-6)在人嗜T淋巴細胞病毒Ⅰ型相關性脊髓病/熱帶痙攣性癱瘓(HAM/TSP)髮病中的作用.[方法]應用免疫放射方法檢測8例HAM/TSP患者血清及腦脊液中IL-6水平.[結果]HAM/TSP 患者血清及腦脊液中IL-6含量分彆為(194.76±30.01) pg/ml;(184.12±36.39) pg/ml,而其他神經繫統疾病(OIND)組血清及腦脊液中IL-6含量分彆為(132.61±21.76) pg/ml;(124. 95±15.39) pg/ml,正常對照組(NC) 組血清IL-6含量為(127.08±22.05) pg/mL.HAM/TSP患者血清及腦脊液IL-6水平均明顯高于正常對照組(P<0.01);但HAM/TSP患者血清中IL-6含量與腦脊液中IL-6含量水平不呈線性相關.[結論]IL-6在HAM/TSP髮病的免疫機製中可能起到重要作用.
[목적]탐토백세포개소6(IL-6)재인기T림파세포병독Ⅰ형상관성척수병/열대경련성탄탄(HAM/TSP)발병중적작용.[방법]응용면역방사방법검측8례HAM/TSP환자혈청급뇌척액중IL-6수평.[결과]HAM/TSP 환자혈청급뇌척액중IL-6함량분별위(194.76±30.01) pg/ml;(184.12±36.39) pg/ml,이기타신경계통질병(OIND)조혈청급뇌척액중IL-6함량분별위(132.61±21.76) pg/ml;(124. 95±15.39) pg/ml,정상대조조(NC) 조혈청IL-6함량위(127.08±22.05) pg/mL.HAM/TSP환자혈청급뇌척액IL-6수평균명현고우정상대조조(P<0.01);단HAM/TSP환자혈청중IL-6함량여뇌척액중IL-6함량수평불정선성상관.[결론]IL-6재HAM/TSP발병적면역궤제중가능기도중요작용.
