药学学报
藥學學報
약학학보
ACTA PHARMACEUTICA SINICA
2001年
2期
140-144
,共5页
金一%内田昌希%汪成发%夏目秀视%杉林坚次%森本雍宪
金一%內田昌希%汪成髮%夏目秀視%杉林堅次%森本雍憲
금일%내전창희%왕성발%하목수시%삼림견차%삼본옹헌
微球%粒子释放系统%皮肤
微毬%粒子釋放繫統%皮膚
미구%입자석방계통%피부
目的 研究微球的粒子大小和超高速氦气气流的压力对释放固体微球经皮给药吸收过程的影响。方法 利用氦气的超高速流体通过对固体粒子进行加速的方法，将药物粉末透过角质层释放到表皮和真皮表面，将固体药物粉末通过皮肤释放到体内。结果 药物导入率依赖于超高速氦气气流的压力和微球的粒子大小，且生物利用度和最高血中浓度也依赖于超高速氦气气流压力的影响。结论 本系统可用于固体药物粉末、多肽类药物、高分子药物以及蛋白性药物的经皮给药。
目的 研究微毬的粒子大小和超高速氦氣氣流的壓力對釋放固體微毬經皮給藥吸收過程的影響。方法 利用氦氣的超高速流體通過對固體粒子進行加速的方法，將藥物粉末透過角質層釋放到錶皮和真皮錶麵，將固體藥物粉末通過皮膚釋放到體內。結果 藥物導入率依賴于超高速氦氣氣流的壓力和微毬的粒子大小，且生物利用度和最高血中濃度也依賴于超高速氦氣氣流壓力的影響。結論 本繫統可用于固體藥物粉末、多肽類藥物、高分子藥物以及蛋白性藥物的經皮給藥。
목적 연구미구적입자대소화초고속양기기류적압력대석방고체미구경피급약흡수과정적영향。방법 이용양기적초고속류체통과대고체입자진행가속적방법，장약물분말투과각질층석방도표피화진피표면，장고체약물분말통과피부석방도체내。결과 약물도입솔의뢰우초고속양기기류적압력화미구적입자대소，차생물이용도화최고혈중농도야의뢰우초고속양기기류압력적영향。결론 본계통가용우고체약물분말、다태류약물、고분자약물이급단백성약물적경피급약。
AIM To investigate the effect of particle size and high speed flow of helium gas on the systemic absorption of indomethacin using a needle-less injection system. METHODS Poly-L-lactic acid microspheres containing indomethacin was prepared by the o/w solvent evaporation technique. After anesthetizing the male hairless rat, microspheres filled in the tube cartridge was accelerated by a stream of helium gas at various velocity in the HeliosTM gun system, and then was introduced to the abdominal skin. RESULTS Introduction of indomethacin to the hairless rat skin was proportionally increased with enhancing the helium pressure (supersonic flow). Bioavailability and Cmax were also dependent on the helium pressure. CONCLUSION This method can be used to deliver the powered drug and/or microparticulate systems into the skin tissues and the systemic circulation.
