CAJ | 학술논문

以乙脒盐酸盐为原料，经环合硝化、氯化、还原、加成脱水、醇解成盐合成了中枢性降压药莫索尼定，总产率为24.8%。在氯化反应中，以三氯氧磷为氯化剂，产率为92.8%。在还原反应中，以铁粉为还原剂，完成反应后进行水蒸气蒸馏，产率为87.7%。
이을미염산염위원료，경배합초화、록화、환원、가성탈수、순해성염합성료중추성강압약막색니정，총산솔위24.8%。재록화반응중，이삼록양린위록화제，산솔위92.8%。재환원반응중，이철분위환원제，완성반응후진행수증기증류，산솔위87.7%。
Moxonidine is known as the central hypotensor of the secondarygeneration.It was synthesized from acetamidine hydrochloride as the starting material via cyclization,nitration,chlorination,reduction,addition and dehydration,alcoholysis and salt formation.The overal yield was 24.8%.The yield of chlorination was 92.8%,using phosphorus oxychloride as the chlorinating agent.The yield of reduction was 87.7%,using iron powder as the reducting agent and steam distillation as the separation method.