CAJ | 학술논문

分析动式吸入对苯二甲酸(TPA)粉尘大鼠支气管肺泡灌洗液(BALF)中细胞与生化反应，各实验组染尘几何平均浓度分别为8.93mg/m3、274.45mg/m3、618.12mg/m3。结果显示，中、高浓度组肺泡巨噬细胞(PAMs)计数比对照组显著减少，酸性磷酸酶(ACP)活性显著升高，高浓度组N－乙酰-β-D-氨基葡糖苷酶(NAG)活性显著高于对照组，提示TPA粉尘吸入对大鼠PAMs有损伤作用；BALF中蛋白质含量变化可能有免疫过程参与。
분석동식흡입대분이갑산(TPA)분진대서지기관폐포관세액(BALF)중세포여생화반응，각실험조염진궤하평균농도분별위8.93mg/m3、274.45mg/m3、618.12mg/m3。결과현시，중、고농도조폐포거서세포(PAMs)계수비대조조현저감소，산성린산매(ACP)활성현저승고，고농도조N－을선-β-D-안기포당감매(NAG)활성현저고우대조조，제시TPA분진흡입대대서PAMs유손상작용；BALF중단백질함량변화가능유면역과정삼여。
The cellular and biochemical effects on bronchoalveolar lavagefluids (BALF) of the rats after inhalation of TPA dust were anal-ysed. The average geometric concentrations of TPA dust in experi-mental groups were 8.93mg/m3, 274.45mg/m3 and 618-12mg/m3 respectively. It was discovered that pulmonary alveo｝ armacrophages (PAMs) in BALF of the rats exposed to TPA dust atthe middle and high concentrations were significantly decreasedwhile acid phosphatase (ACP) was significantly increased, andNAG in the high concentration group was significantly increasedas compared with those in the control. The results showed thatPAMs of the rats could be injured. The change inthe protein con-tent In BALF suggested that imrrlune process might be involvedin the lung damage induced by TPA inhalation.